聚乳酸材料的仿生修饰研究进展

Progress of Bio-inspired Modification of Polylactides

聚乳酸是生物可降解、生物相容性材料,但由于存在亲水性差、缺乏细胞识别位点等缺陷,限制了其在生物医学工程中的应用。模拟细胞与基质相互作用的特点以及细胞外基质的特性,通过表面修饰、本体改性和复合加工的方法在聚乳酸中引入蛋白胶原、活性肽、多糖以及羟基磷灰石等生物活性分子,实现聚乳酸的仿生修饰,能够有效提高聚乳酸材料的生物学功能。综述了利用这些生物活性分子对聚乳酸进行仿生修饰的研究进展。

Polylactides have good biodegradability and biocompatibility, but poor hydrophilicity and lack of cell recognition sites. Their applications in biomedicine engineering have been limited. Mimicking cell-matrix interaction and the properties of extracellular matrix（ECM）, bio-inspired modification of polylactides has been achieved by surface modification, bulk modification and composition with bioactive molecules such as collagen, short peptide sequences derived from intact ECM proteins, polysaccharides, as well as hydroxyapatite. After the modification, the bio-function of polylactides has been greatly improved. The advances in the modification of polylactides using these bioactive molecules are reviewed.