新生儿缺氧缺血性脑病血小板参数的变化及意义

Changes and significance of platelet parameters in neonatal hypoxic-ischemic encephalopathy

目的探讨新生儿缺氧缺血性脑病(HIE)血小板参数的变化及临床意义。方法对204例HIE患儿进行临床分度,于急性期进行血小板参数的测定,并于恢复期复查,了解其动态变化情况。并以120例正常足月新生儿作为对照。结果(1)HIE患儿急性期血小板(PLT)总数较正常儿明显降低(P<0.01),平均血小板体积(MPV)和血小板体积分布宽度(PDW)较正常儿明显增高(P<0.05)。恢复期PLT、MPV、PDW与正常组之间差异无统计学意义(P>0.05)。(2)HIE患儿PLT随HIE病情加重而降低(P<0.01),而MPV、PDW则随病情加重增大(P<0.01,P<0.05)。结论动态观察HIE患儿血小板参数,可作为判断HIE病情严重程度的指标。

Objective To explore the changes of platelet parameters and their clinical significance in neonatal hypoxic-ischemic encephalopathy （HIE）. Methods Two-hundred and four children with clinical HIE in the acute phase were determined platelet parameters and redetected in recovery period for understanding the dynamic changes. And 120 normal full-term newborns were as controis. Results （1）The total number of platelet （PLT） in children with acute phase of HIE was significantly lower than that in the normal infants （P〈0. 01） ,mean platelet volume （MPV） and platelet volume distribution width （PDW） were significantly higher than those in the normal infants （P〈0.05）. PLT, MPV,PDW in recovery period and normal group had no significant difference （P 〉0.01）. （2）PLT decreased with exacerbation in HIE patients（P〈0.01） ,while MPV and increased（P〈0.01, P〈0.05）. Conclusion Dynamic observation of platelet parameters in children with HIE could be used as indicator of the severity of the disease.