孕激素受体的表达与局部晚期乳腺癌TC化疗方案敏感性的观察

Effect of PR expression on sensitivity of chemotherapy with TC regimen in locally advanced breast cancer

目的探讨孕激素受体(PR)不同表达对局部晚期乳腺癌TC新辅助化疗方案的敏感性关系,为选用TC新辅助化疗提供依据。方法采用免疫组化EnVision法,检测57例局部晚期乳腺癌患者化疗前PR的表达情况,比较PR阴性病例与PR阳性病例对TC化疗方案的敏感性。结果PR阴性组的敏感性为81.48%(22/27),PR阳性组的敏感性为53.33%(16/30),两组比较差异有统计学意义(P<0.05)。结论说明PR阴性的乳腺癌患者对TC新辅助化疗方案更敏感。PR阴性可作为局部晚期乳腺癌选用TC新辅助化疗方案的依据之一。

Objective To investigate the effect of PR expression on the sensitivity of chemotherapy with TC regimen in locally advanced breast cancer patients. Methods The expression of PR was detected by EnVision immunobistocbemistry in breast cancer tissues before neoadjuvant chemotherapy with TC regimen in corresponding patients,and the correlation of PR expression with the sensitivity of chemotherapy were studied in 57 PR negative or positive patients. Results The sensitivity was 81.48% （22/27）in PR negative breast tumours,and was 53.33 % （16/30） in PR positive breast tumours with TC regimen in locally advanced breast cancer patients,and there was significant difference of sensitivity between breast cancer patients with PR negative and positive tumours（P 〈0.05）. Conclusion PR negative breast cancer patients were more sensitive to neoadjuvant chemotherapy. PR negative may serve as one of good markers for prediction of sensitivity of neoadjuvant chemotherapy with TC regimen in locally advanced breast cancer patients.