摘要
以熔融缩聚制得的聚乳酸(PLA)作为载体,以聚乙烯醇为分散剂,二氯甲烷为溶剂,采用乳化-溶剂蒸发法制备聚乳酸硝苯地平(PLA/NFD)缓释微球。通过红外光谱(FT-IR)和生物显微镜对聚乳酸硝苯地平缓释微球进行了表征,并用紫外分光光度法探讨了聚乳酸硝苯地平缓释微球的释药性能。结果表明:聚乳酸硝苯地平缓释微球呈现以光滑完整的球形,且聚乳酸和硝苯地平药物能够有机地结合为一体。合成的聚乳酸硝苯地平球形微球具有明显的缓释作用,而且增大硝苯地平/聚乳酸投药比,会提高微球的释放度,但包封率下降。
The polylactic acid/Nifedipine （PLA/NFD） microspheres were prepared by the solvent evaporation method, choosing the methylene chloride as a good solvent and the poly vinyl alcohol （PVA） as a dispersed agent, and the polylactic acid （PLA） prepared by melting polycondensation as a drug carrier. The PLA/NFD microspheres were characterized through infrared spectroscopy （FT-IR） and biological microscope. The released properties were discussed via ultraviolet spectrophotometry. The results showed that the PLA/NFD microspheres were smooth pherical and polylactie acid integrated into nifedipine. The PLA/NFD microspheres exhibited remarkable sustained-release properties. Moreover, the released degree of PLA/NFD microspheres was improved and its envelopment rate was decreased with the increase of the ratio of NFD to PLA .
出处
《化学工程师》
CAS
2009年第11期8-11,共4页
Chemical Engineer
基金
河南工业大学校科研基金项目(07XJC006)
关键词
聚乳酸
硝苯地平
溶剂蒸发法
微球
药物缓释
polylactic acid
nifedipine
solvent evaporation method
microspheres
drug sustained-release
