慢性肺心病合并心力衰竭与血尿酸水平的临床分析

Clinical Analysis of Chronic Pulmonary Heart Disease Complicated with Heart Failure and Serum Uric Acid Level

目的：探讨慢性肺心病合并心力衰竭患者血尿酸水平的临床意义。方法：68例肺心病合并心力衰竭患者检测治疗前及治疗2周后血清尿酸及动脉血气分析，根据心功能状况将患者分成3组：A组心功能Ⅰ～Ⅱ级，B组心功能Ⅲ级，C组心功能Ⅳ级（NYHA心功能分级法），并与正常对照组50例比较。结果：治疗前肺心病组血尿酸明显高于正常对照组，有显著性差异（P〈0．01）。3组不同程度心力衰竭肺心病患者的血尿酸比较：C组与A组间有显著性差异（P〈0.01），C组与B组间有显著性差异（P〈0.05），A组与B组间无显著性差异（P〉0．05）。治疗2周后，随着缺氧的改善，肺心病患者血尿酸水平与治疗前比较明显下降（P〈0.01）。结论：血尿酸水平高低与肺心病合并心力衰竭的程度有关。血尿酸测定可作为评估肺心病严重程度及预后的指标之一。

Objective： To investigate clinical implications of serum uric acid levels in patients with chronic pulmonary heart disease complicated with heart failure. Methods：Two weeks before and after the therapy, the value of serum uric acid and arterial blood gas analysis in 68 cases with chronic pulmonary heart disease complicated with heart failure were recorded and compared to the normal control group（50 cases）. The patients were divided into three groups： group A （class Ⅰ-Ⅱ）,group B（elass Ⅲ）, and group C（class Ⅳ）[New York Heart Assoeiation（NYHA）]. Results： The serum uric acid levels of chronic pulmonary heart disease complicated with heart failure groups was higher than the normal control group（P〈0. 01）before therapy. Serum uric acid levels were significantly different between groups C and A（P〈 0. 01）,groups C and B（P〈0. 05）,but not between groups A and B（P〉0. 05）. After the therapy of two weeks, the value of serum uric acid decreased obviously in chronic pulmonary heart disease groups（P〈0. 01） . Conclusion： The detection of serum uric acid level is significant to evaluate the situation of. patient with heart failure. The levels of serum uric acid can be used as a marker to predict the development of chronic pulmonary heart disease.