VEGF表达与鼻咽癌血管生成、瘤细胞增殖及预后的关系

Relationship between expression of VEGF with angiogenesis,tumor cell proliferation and prognosis in nasopharyngeal carcinoma

目的探讨血管内皮生长因子(VEGF)表达与鼻咽癌(NPC)血管生成、肿瘤细胞增殖及预后的关系。方法选取有明确病理诊断、临床资料完整并随访5 a以上的86例NPC患者活检标本,采用免疫组织化学技术检测活检标本中VEGF、微血管密度(iMVD)和增殖细胞核抗原(PCNA)的表达,并分析其与临床病理及预后的关系。结果全组VEGF阳性表达率69.9%(60/86),与iMVD、PCNA呈显著正相关,与组织学分级、原发灶范围、淋巴结转移、临床分期及生存期亦具相关性。结论NPC组织中VEGF过表达可能参与NPC发生发展,可作为判断NPC恶性程度、侵袭能力和预后的指标。

Objective To evaluate the expression of vascular endothelial growth factor （VEGF） and its relationship with tumor cell proliferation and prognosis in nasopharyngeal carcinoma （NPC）. Methods The expression of VEGF, intratumoral microvascular density （iMVD） and tumor cell proliferation （PCNA） was measured with immunohistochemieal method in NPC patients followed up over 5 years. Results Positive expression rate of VEGF was 69.9% （60/86）. VEGF expression was positively correlated with iMVD and PCNA, and also correlated with the tumor pathological grade, extent of primary lesion, lymph node metastasis, clinical stage and survival time. Conclusion VEGF plays an important role of prognosis in NPC through regulation of angiogenesis and tumor cell proliferation.