摘要
目的：筛选对肺癌化疗的敏感性药物，为临床合理选择用药提供依据。方法：应用四甲基偶氮唑盐（ＭＴＴ）法，对６０例人体肺癌原代细胞进行９种化疗药物的敏感性测定。结果：观察到不同人的肺癌对同一化疗药物的敏感性不同，不同肺癌有各自的药敏谱。各药中以顺铂、丝裂霉素、５氟脲嘧啶、平阳霉素的敏感率为高。结论：在肺癌药物试验中，ＭＴＴ法是可行的，对临床化疗用药有指导意义。
Objective:To select sensitive anticancer chemotherapy agents for clinical treatment of lung cancer.Methods:Chemosensitivities of nine antitumor drugs on 60 cases of lung cancer were assayed in vitro using MTT colorimetry 3 (4,5 dimethylthiazol z yl) 2,5 diphenyltetrazolium bromide,MTT .Results:Chemosensitivity of chemotherapy agents on lung carcinoma cells showed remarkable changes and each kind of carcinoma had it's own chemosensitivity spectrum.The agents which showed high chemosensitivity were cisplatin mutamycin,5 fluorouracil,bleocin.Conclusion:MTT colorimetry as an assay has a clinical reference in selection of chemo agents for lung cancer.
出处
《河北医科大学学报》
CAS
1998年第6期335-337,共3页
Journal of Hebei Medical University
关键词
肺肿瘤
药物疗法
比色法
药敏试验
lung neoplasms/drug ther
drug screening
colorimetry
