心脑舒通胶囊对糖尿病不稳定型心绞痛患者血管内皮功能的影响

Effect of Xinnaoshutong Capsule on Vascular Endothelium Function in Patients with Type 2 Diabetes Mellitus Complicated with Unstable Angina

目的探讨心脑舒通胶囊对2型糖尿病不稳定型心绞痛患者的临床疗效及其对血管内皮功能的影响。方法64例2型糖尿病不稳定型心绞痛患者,经2周导入期治疗后,按随机数字分为治疗组(32例,采用心脑舒通胶囊联合鲁南欣康片治疗),对照组(32例,单用鲁南欣康片治疗),治疗期均为6个月。随访治疗期间以日记卡形式记录心绞痛的发作频率和硝酸甘油的应用情况,观察两组治疗前后肱动脉超声检测血管内皮功能的变化。结果两组心绞痛发作次数均明显减少,而两组间比较无统计学意义。但心绞痛持续时间和硝酸甘油用量情况,两组间比较差异有统计学意义(P<0.01)。对照组治疗前后肱动脉内径基础值分别为(3.68±0.56)mm和(3.70±0.58)mm,反应性充血前后内径分别为(5.44±0.81)%和(5.68±0.83)%,含硝酸甘油前后内径分别为(19.8±4.9)%和(20.1±5.2)%。治疗组治疗前后肱动脉内径基础值分别为(3.73±0.62)mm和(3.71±0.59)mm,含服硝酸甘油前后内径分别为(18.8±4.5)%和(19.2±5.8)%,但反应性充血前肱动脉内径分别为(5.69±0.79)%和(9.56±3.82)%(P<0.01)。结论心脑舒通胶囊能改善2型糖尿病不稳定型心绞痛的临床症状和血管内皮功能,是安全,有效的辅助治疗药物。

Objective To investigate the effects of Xinnaoshutong capsule on vascular endothelium in patients with type 2 diabetes mellitus（T2DM） tromplicated with unstable angina（UA）. Methods After two weeks of runin,sixty - four patients with T2DM complicated with UA were randomly divided into two groups：The treatment group （n = 32） treated by Xinnaoshutong capsule and isosor bide mononitrate tablets and control group（n=32）treated by isosorbide mononitrate tablets for six months. During the treatment period,the episodes of angina attack and condition of rescue medication were recorded in the daily card. Brachial arterial changes of endothelium - dependent relaxin function were measured by B- ultrasongraphy before and after treatment. Results The episodes of angina attack were decreased in two groups, but there was no different between the two groups. There were significantly different in the time of angina arrack and＂ rescue medication between the two groups（P〈0.01）. In the control group.the basal value of braehial arterial inner diameter was 3. 68±0.56 mm and 3.70±0.58 mm before and after treatment respectively,those before and after responsive congestion was （5.44±0. 81） VS （5.68±0. 83） % and those before and after taking nitroglycerin was （19.8±4.9） % and （20.1±5.2） %. In treatment group, the corresponding basal value was （3.73±0.62） mm VS （ 3.71±0.59 ） ram, and those after taking nitroglycerin （18.8±4.5）% VS （19.2±5.8）%. But those before and after responsive congestion [（5.69±0. 79）% VS （9.56±3. 82%）] did show significant difference（P〈0.01）. Conclusion Xinnaoshutong capsule was safe more effective,which could improve symptoms and the vascular endothelial function in patients with T2DM complicated with UA.