闭式引流联合尿激酶及恩度治疗恶性包裹性胸腔积液初步探讨

Preliminary discussion for the treatment of malignant pleural effusion with urokinase and endostar closed drainage and urokinase

目的观察胸腔中心静脉导管闭式引流联合胸腔内注射尿激酶及恩度治疗恶性包裹性积液的疗效及副作用。方法8例诊断为恶性包裹性胸腔积液患者,行胸腔中心静脉导管闭式引流,胸腔注入尿激酶10万U,每天一次,注入尿激酶后闭管4h,再充分引流后胸腔注入恩度(60mg),视胸水吸收情况一周后可以重复,同时给予静脉化疗,化疗方案据肿瘤类型给予标准治疗方案。结果就胸水控制疗效,8例患者7例显效,1例有效,有效率100%,无明显副作用。结论胸腔中心静脉导管闭式引流联合尿激酶、恩度治疗恶性胸腔积液有效、安全,值得进一步观察应用。

Objective To observe the effectiveness and side effect for the treatment of malignant encapsulated pleural effusion with. Methods 8 patients sufferred from malignant encapsulated pleural effusion were treated with U- rokinase And Endostar by Closed Drainage And infusion of Urokinase and Endostar which can be duplicaded in the sight of the volume of absorption of pleural effusion a week later. Results The effective percentage was 100% and no side effects were found. Conclusions Methods with closed drainage and Urokinase and Endostai was effective and safe for the treatment of malignant pleura1 effusion. Further research may be better.