肥胖患者血清单核细胞趋化蛋白1浓度与葡萄糖钳夹试验胰岛素敏感性的关系

Relationship between serum monocyte chemoattractant protein-I concentration and insulin sensitivity by glucose clamp in obese patients

血清单核细胞趋化蛋白1（MCP-1）浓度随正常人[（65．6±17．7）ng／L]、体重指数〉25kg／m^2的糖耐量正常者[（136．8±57．4）ng／L]和超重或肥胖的2型糖尿病患者逐步升高[（189．4±72．1）ng／L，均P〈0.01]，胰岛素介导的葡萄糖代谢率（Rd）则降低[（10．66±1．68，6．11±2．06，4．86±1．38）mg·kg^-1·min^-1，P〈0．05或P〈0．01]。部分2型糖尿病患者（n=13）经12周罗格列酮治疗后，MCP-1降低[（113．0±35.7vs186．9±64.3）ng／L，P〈0．01]，Rd升高[（6．34±1．18vs4．97±1．51）mg·kg^-1·min^-1，P〈0．01]。

Serum monocyte chemoattractant protein-1 （MCP-1） was increased progressively in healthy, obese（ body mass index〉25 kg/m^2 ） subjects, and obese type 2 diabetic patients [ （65.6±17.7,136.8 ±57.4 and 189.4±72.1 ） ng/L, all P〈0.01 ], while insulin-mediated glucose disposal （Rd） was decreased [ （ 10.66± 1.68, 6.11±2.06 and 4.86± 1.38） mg·kg^-1·min^-1 ,P〈0.05 or P〈0.01 ]. After 12-week treatment with rosiglitazone, MCP-1 was decreased[ （ 113.0±35.7 vs 186.9±64.3） ng/L, P〈0.01 ] and Rd increased [ （6.34± 1.18 vs 4.97±1.51）mg·kg^-1·min^-1 ,P〈0.01 ] .