丛状神经鞘瘤

Plexiform schwannoma:a case report

报告1例丛状神经鞘瘤。患者男,74岁。因右胸部皮肤结节50年就诊。组织病理检查示真皮中散在分布多个大小、形态不一的肿瘤细胞团块,其周围有完整的包膜。肿瘤团块主要由许多梭形细胞组成,核深染,染色质丰富,有异形。免疫组化染色显示几乎所有肿瘤细胞的细胞核和细胞质S-100蛋白均阳性,而Ki-67阴性。符合丛状神经鞘瘤的诊断。组织病理上该病需与恶性周围神经鞘瘤鉴别。

A case of plexiform schwannoma is reported. A 74-year-old man presented with a 50-year history of nodule on his right chest. Histological examination showed muhinodular well-defined eneapsuled tumour masses of different sizes and shapes in the dermal. The tumor was composed of dense proliferation of chromatin-rlch spindle shaped cells with atypia nu- clei. Immunohistochemieal staining with anti-S-100 protein was positive in the nuclei and cytoplasm of nearly 100% of the tumor cells. Ki67 was negative. These findings were consistent with plexiform schwannoma. Differential diagnosis must be made with malignant peripheral nerve sheath tumour in histopathology.