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荷瘤SCID-hu鼠模型及其肿瘤实验研究现状

Current Situation of Research on Humanized SCID Mice Bearing Tumor Model and Its Tumor Experiment
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摘要 严重联合免疫缺陷鼠(severe combined immune deficiency mice,SCID)具有T、B淋巴细胞联合免疫缺陷等生物学特性,可以将人类有关免疫细胞、免疫组织和器官移植入其体内进行人免疫功能重建-SCID-hu鼠。荷瘤SCID-hu鼠模型为人类肿瘤的发病机制、生物治疗等方面的研究提供了良好的实验平台。 Severe combined immunodeficient mice（SCID） have biological characteristics of T,B lymphocytes combined immune deficiency.Human immune cells,tissues and organs are transplanted into their bodies to reconstruct human immune function-SCID-hu mice.In recent years,many tumor-bearing SCID-hu mouse models were established,which provided a good experimental platform for the research of pathogenesis of human tumors and biological treatments.
作者 周海滨 颜汝平 王剑松
机构地区 昆明医学院第二附属医院泌尿外科
出处 《中国比较医学杂志》 CAS 2009年第10期64-67,共4页 Chinese Journal of Comparative Medicine
关键词 严重联合免疫缺陷鼠 小鼠 SCID-hu 模型 动物 Severe combined immunodeficient mice（SCID） Mice SCID-hu Model animal
分类号 R73-3 [医药卫生—肿瘤]
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参考文献18

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二级参考文献6

  • 1谢斌辉,彭宝岗,梁力建.转染肿瘤总RNA的DC疫苗诱导抗肝癌特异性免疫[J].中国病理生理杂志,2005,21(5):919-922. 被引量：3
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中国比较医学杂志
2009年 第10期

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