精神分裂症患者工作记忆不同认知成分的fMRI研究

An fMRI study for different cognition components of working memory in schizophrenia patients

目的:采用事件相关功能磁共振成像(ER-fMRI)探讨精神分裂症患者与正常对照组执行工作记忆不同认知成分即编码、维持和提取过程的神经机制差别。方法:使用fMRI技术,观察16名正常受试者和20名精神分裂症患者在执行Sternberg项目认知任务(SIRT)的编码、维持和提取过程时的激活脑区。结果:与正常组比较,患者组工作记忆不同认知过程的执行脑区激活程度增加,编码期激活增加脑区为右侧楔前叶,维持期激活增加脑区为左侧PMA、左侧DLPFC、右侧楔前叶及左侧VLPFC,提取期激活增加脑区为左侧PMA,而且患者组还激活了更多皮层下结构、初级运动皮层及左侧颞叶语言相关脑区。结论:精神分裂症患者工作记忆编码、维持和提取成分的一些执行脑区皮层效率功能低下。

Objective： To investigate the difference of neural mechanism for different cognition components with encoding, maintenance and retrieval process of working memory（WM） between schizophrenia patients and normal subjects using event-related fMRI （ER-fMRI）. Methods： Sixteen normal subjects and twenty schizophrenia subjects completed a Sternberg item recog- nition task using fMRI. Brain activation regions for encoding, maintenance and retrieval process were obtained. Result： Compared to normal subjects, some functional regions associated with encoding, maintenance and retrieval process showed increased activation in schizophrenia patients, i.e. right precuneus for encoding process, left PMA, left DLPFC, right precuneus and left VLPFC for maintaince process, left PMA for retrieval process. In addition, subcortical structures, primary motor cortex and some verbal regions in left temporal lobe also showed more activation. Conclusion： Some functional regions associated with encoding, maintenance and retrieval process showed relatively inefficiency in schizophrenia patients.