寄生虫感染与炎症性肠病负相关的研究

The negative correlation study of parasitic infection and inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)的流行病学研究显示,无论是溃疡性结肠炎(UC)还是克罗恩病(CD)的发病,均与寄生虫感染呈负相关。这一现象启迪人们运用动物实验、临床试验来探讨潜在的机制。寄生虫,尤其是蠕虫感染后,宿主胃肠道主要出现Th2型免疫应答反应。机体的免疫活性细胞活化并表达细胞因子,破毁和驱除寄生虫。肠道病变修复后的宿主具有抵御IBD发病和病变复发的能力。人工感染蠕虫的研究显示,IBD患者肠道病变程度显著减轻。以上研究结果有助于了解IBD胃肠道免疫损伤的机制,拓展新的治疗学研究。

Epidemiology investigations demonstrate significantly negative correlation between the parasitic infection and the incidence of inflammatory bowel disease（IBD） which includes ulcerative colitis（UC） and Crohn＇s disease（CD）.Both animal and clinical studies are employed to explore the mechanism.After parasites especially helminthic infected,the host of gastrointestinal tract mainly appears the Th2 immune response.Immunocytes are activated and cytokines are secreted,resulting in elimination of the invaded parasites as well as recovery of intestinal injury.Then,the host after the repair of intestinal lesions will be resistant to the onset or relapse of IBD.Intestinal damage would be ameliorated after artificial infection with helminth ova in IBD.These studies are helpful to elucidate the mechanism of intestinal damages and develop novel therapeutic strategies.