摘要
目的:研究喉癌组织中Stat3及其靶基因Cyclin D1蛋白表达及两者的相关性。方法:应用免疫组织化学方法,研究喉癌组织中Stat3和Cyclin D1的表达情况,并且对Stat3表达的相关临床病理因素进行分析。结果:喉癌组织中Stat3蛋白、Cyclin D1蛋白高表达,两者表达强度具有相关性(r=0.304,P<0.01)。结论:喉癌中活化的Stat3可能通过促进靶基因CyclinD1转录而发挥其促进癌变的作用。
Objective:To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method. Method:With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinicatpathological factor. Result:Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship. Conclusion:Active Stat3 may promote the transcription of target gene Cyclin D1, which could accelerate carcinomatous change.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2009年第21期982-984,988,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery