喉癌组织中Stat3及其靶基因Cyclin D1蛋白的表达及其相关性研究

To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm by immunohistochemistry

目的:研究喉癌组织中Stat3及其靶基因Cyclin D1蛋白表达及两者的相关性。方法:应用免疫组织化学方法,研究喉癌组织中Stat3和Cyclin D1的表达情况,并且对Stat3表达的相关临床病理因素进行分析。结果:喉癌组织中Stat3蛋白、Cyclin D1蛋白高表达,两者表达强度具有相关性(r=0.304,P<0.01)。结论:喉癌中活化的Stat3可能通过促进靶基因CyclinD1转录而发挥其促进癌变的作用。

Objective：To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method. Method：With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinicatpathological factor. Result：Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship. Conclusion：Active Stat3 may promote the transcription of target gene Cyclin D1, which could accelerate carcinomatous change.