晚期糖基化终产物受体在喉鳞状细胞癌中的表达及临床意义

Expression of RAGE in laryngeal squamous cell carcinoma and clinical significance

目的:探讨晚期糖基化终产物受体(RAGE)在喉鳞状细胞癌(LSCC)中的表达与临床意义。方法:采用免疫组织化学SP法和RT-PCR法测定RAGE在37例LSCC中的表达,并以喉癌旁组织作为对照组,结合LSCC的临床和病理特征进行分析。结果:RAGE表达于细胞质与细胞膜中,在LSCC中的阳性率(51.4%)明显高于喉癌旁组织(25.0%)(P<0.05)。在不同的病理分级中,RAGE的表达差异有统计学意义(P<0.01)。结论:RAGE的表达与LSCC的生长、分化有关。

Objective：To study the expression and clinical significance of receptor for advanced glycation end products （RAGE） in laryngeal squamous ceil carcinoma （LSCC）. Method： Immunohistochemical staining was used to detect the expressions of RAGE protein and semiquantitative method of reverse transcriptase polymerase chain reaction （RT PCR） was used to analyze the expression level of RAGE mRNA in LSCC tissues and laryngeal nor real tissues of 37 cases, respectively. Result： The mRNA and protein expression of RAGE was significantly higher in LSCC than that in normal laryngeal tissues（P〈0.05）, correlated with differentiation（P〈0.01）, but not with tumor stage and location（P〉0.05）. Conclusion： The expression levels of RAGE were significantly higher in LSCC than these in laryngeal normal tissues, RAGE is involved in differentiation of LSCC.