重症急性胰腺炎实验动物模型的研究进展

Advances in the development of experimental animal models of severe acute pancreatitis

为探讨重症急性胰腺炎(severe acute pancreatitis,SAP)的病因、发病机制、病理生理变化及其治疗方法,已用多种方式建立了活体动物SAP模型.鉴于各种活体SAP模型能在不同侧面模拟人类SAP病变过程,但操作及控制各异、部分便于动态观察各项指标变化及治疗效果,可根据不同的实验目的选择合适、操作简单、重复性好的建模方案进行研究.本文简述目前SAP研究现状,启迪未来探索方向.

In order to offer clues to the etiology, patho-genesis, pathophysiology and therapy of severe acute pancreatitis （SAP）, multiple animal models of SAP have been established. These animal models can simulate different aspects of the disease process of human SAP. Due to different manipulation protocols used in the development of animal models, these animal models can meet different research needs. A suitable, simple and reproducible animal model should be selected based on experiment purposes. In this article, we will briefly review the recent advances in the development of animal models of SAP and high-light the direction of future research.