兔肝动脉插管技术的方法学及DSA表现

Comparison of transfemoral hepatic artery catheterization and direct hepatic artery catheterization via laparotomy in rabbits

目的:探讨实验兔肝动脉插管的实验方法.方法:大耳白兔24只,随机等分为2组,实验组,经股动脉穿刺插管至肝动脉;对照组,剖腹下直视穿刺插管至肝动脉,比较2组的手术操作时间及手术成功率.结果:实验组的手术成功率为91.67%(11/12),对照组为75%(8/12),两者相比无显著性差异(P>0.05);实验组的手术操作时间为41.5±3.6min,对照组为58.6±5.4min,两者相比有显著性差异(P<0.05).结论:实验兔进行股动脉穿刺插管进行肝动脉灌注的方法简单、容易掌握、成功率高,适用于研究药物或细胞悬液经肝动脉灌注对肝脏的作用.

AIM： To compare the operation duration and operation success rate between transfemoral hepatic artery catheterization and direct hepatic artery catheterization via laparotomy in rabbits.METHODS： Twenty-four rabbits were randomly divided into two groups： control group and study group. Rabbits in the study group underwent transfemoral hepatic artery catheterization, while those in the control group underwent direct hepatic artery catheterization via laparotomy. The operation duration and operation success rate were compared between the two groups.RESULTS： No significant difference was noted in the operation success rate between the study group and the control group [91.67% （11/12） vs 75% （8/12）, P 〉 0.05]. The mean operation duration was significant lower in the study group than in the control group （41.5±3.6 min vs 58.6±5.4 min, P 〈 0.05）.CONCLUSION： Transfemoral hepatic artery catheterization is simple, has a high success rate, and is suitable for hepatic artery infusion therapy in rabbits.