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炎症反应及细胞因子与糖尿病视网膜病变 被引量：12

Relationship between diabetic retinopathy and inflammatory reaction and cytokine
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摘要 糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病最主要并发症之一,严重影响人类健康及生活质量,其发病机制尚未清楚。有研究表明炎症反应及细胞因子与DR的发生发展密切相关,我们就近年来相关研究进展作以综述。 Diabetic retinopathy is one of the most serious complications of diabetes mellitus,which affects the health and quality of life seriously.The current studies demonstrate that inflammatory reaction and cytokine play a major role in the development of diabetic retinopathy.This article reviews current studies about inflammatory factor and cytokine.
作者 徐晓鹤 陈晓隆 刘鹤南
机构地区 中国医科大学盛京医院眼科
出处 《国际眼科杂志》 CAS 2009年第11期2136-2138,共3页 International Eye Science
关键词 糖尿病视网膜病变 炎症反应 细胞因子 diabetic retinopathy inflammatory reaction cytokine
分类号 R774.1 [医药卫生—眼科]
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二级参考文献33

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  • 2Hernandez C,Segura RM,Fonollosa A,et al.Interleukin-8,monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy.Diabet Med,2005,22:719-722.
  • 3Mohr S.Potential new strategies to prevent the development of diabetic retinopathy.Expert Opin Investig Drugs,2004,13:189-198.
  • 4Qiao H,Sonoda KH,Sassa Y,et al.Abnormal retinal vascular development in IL-18 knockout mice.Lab Invest,2004,84:973-980.
  • 5Sfikakis PP,Markomichelakis N,Theodossiadis GP,et al.Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab.Diabetes Care,2005,28:445-447.
  • 6Ben-Mahmud BM,Mann GE,Datti A,et al.Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells:significance of core2 GlcNAc-T in diabetic retinopathy.Diabetes,2004,53:2968-2976.
  • 7Shishodia S,Aggarwal BB.Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation,suppresses expression of anti-apoptotic gene products,and enhances apoptosis.J Biol Chem,2004,279:47148-47158.
  • 8Yamagishi SI,Inagaki Y,Nakamura K,et al.Pigment epithelium-derived factor inhibits TNF-α-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation.J Mol Cell Cardiol,2004,37:497-506.
  • 9Das A,Menicucci G,Giebel S,et al.Plasminogen activator inhibitor-1(PAI-1) in early diabetic retinopathy and retinal neovascularization.Invest Ophthalmol Vis Sci,2005,46:2367-2373.
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国际眼科杂志
2009年 第11期

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