贝达飞微生态制剂治疗小儿肺炎继发腹泻的疗效观察及相关因素分析

Clinical effect of beidafei probiotics treatment on secondary diarrhea of children pneumonia and analysis of related factors

目的:探讨小儿肺炎继发腹泻的危险因素及采用贝达飞微生态制剂对其治疗的临床效果.方法:347例肺炎患儿为研究对象,对小儿肺炎继发腹泻相关因素进行Logistic回归分析,筛选小儿肺炎继发腹泻的危险因素;110例肺炎继发腹泻患儿随机分为治疗组和对照组,治疗组采用贝达飞微生态制剂治疗,对照组采用乳酶生片治疗,治疗结束后评价临床疗效.结果:①单因素分析显示:患儿年龄、住院天数、住院后有无侵入操作、微生态制剂的应用、居住地、病情严重程度、血中性粒细胞计数、血红蛋白数量、激素应用与小儿肺炎继发腹泻有关.非条件Logistic多因素回归分析筛选出2个危险因素:患儿年龄小、入院后有侵入性操作;1个保护因素:微生态制剂的应用.②治疗组临床疗效总有效率为92.6%,显著高于对照组(61.4%),相比较有统计学差异(P<0.05).结论:患儿年龄小、住院期间有进行侵入性操作为小儿肺炎继发腹泻的危险因素;采用贝达飞微生态制剂治疗小儿肺炎继发腹泻疗效确切,值得临床上推广应用.

AIM：To investigate the risk factors of secondary diarrhea of children pneumonia （SDCP） and clinical effect of beidafeiprobiotics. METHODS：347 cases of children pneumonia were studied,for children with pneumonia secondary to diarrhea-related factors Logistic regression analysis; 110 cases of SDCP were randomly divided into treatment group and control group,the treatment group was given beidafei probiotics treatment,the control group was given lactasin tablets treatment. After treatment the clinical effect was evaluated. RESULTS： （1）ANOVA indicated： children age, hospital days, whether invasive operation after hospitalization, application of probiotics, residence place, severity of disease, blood neutrophil count, hemoglobin quantity, the use of hormone were related with SDCP. Nonconditional multiplicity logistic regression model analysis showed that younger children and during hospitalization for invasive procedures were risk factors of SDCP. The application of probiotics was an independent protective factor of SDCP. （2）The total effective rate of the treatment group was 92.6%, significantly higher than that of the control group （ 61.4% ）, the difference was significant （ P 〈 0. 05 ）. CONCLUSION： The younger children and during hospitalization for invasive procedures were risk factors of SDCP. The clinical effect for beidafei probiotics treatment of SDCP is curative, which is worth clinical application.