survivin,P21在人口腔扁平苔藓及口腔鳞癌中的表达

Expression of survivin and P21 in oral Lichen planus and oral squamous cell carcinoma

目的:探讨凋亡抑制因子survivin,P21基因在口腔扁平苔藓(OLP)、口腔鳞状细胞癌(OSCC)中的表达意义及其关系.方法:采用免疫组化SP法检测26例正常口腔黏膜组织、40例糜烂型OLP组织及40例OSCC组织survivin,P21基因的表达,并分析其相关性.结果:survivin蛋白、P21蛋白在正常口腔黏膜组织、OSCC组织和糜烂型OLP组织中的表达差异均有显著性(P<0.05).survivin蛋白与P21蛋白在三种组织中的表达呈正相关(rs=0.658,P<0.05).结论:sur-vivin,P21与OLP向OSCC转变有关,它们在OSCC的发生发展中起重要作用.

AIM：To study the expression of survivin,a member of inhibitor of apoptosis protein family,and P21gene and their relationship with oral lichen planus（OLP） and oral squamous cell carcinoma （OSCC）. METHODS：Immunohistochemical technique S-P was used to detect the expression of survivin and P21 protein in 40 cases of OSCC,40 cases of OLP tissues and 26 cases of normal oral mucosa,and their relationship was analyzed. RESULTS：The expression of survivin and P21 were significantly different in normal oral mucosa,OLPand OSCC tissues （P 〈0.05）. The expressions of survivin and P21 showed a positive correlation in three types of tissues （ rs = 0. 685 ）. CONCLUSION ： Survivin gene and P21 gene involve in the transformation of OLP to OSCC. Survivin gene and P21 gene are important in the development and progress of OSCC .