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刚地弓形虫基因工程疫苗 被引量：1

Genetic Engineering Vaccine of Toxoplasma Gondii
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摘要 弓形虫疫苗是预防弓形虫感染的最有效手段之一。随着生物学研究技术的不断进步,弓形虫疫苗的研究也不断深入完善。介绍了近些年发展起来的基因工程疫苗的最新研究进展,以期望在对现有研究成果总结的基础上,为今后的科研提供新的视角和方向。 The Toxoplasma gondii vaccine is the best way to prevent Toxoplasma gondii improvement of the biological techology promots the study of Toxoplasma gondii vaccine. The infection newest The study progresses of Toxoplasma gondii genetic engineering vaccine, which is summarized on the basis of the current study results, is respected to provide new aspects of the Toxoplasma gondii vaccine study for the researches.
作者 徐安健 谷俊朝
机构地区 首都医科大学附属北京友谊医院北京热带医学研究所
出处 《中国生物工程杂志》 CAS CSCD 北大核心 2009年第11期102-105,共4页 China Biotechnology
关键词 弓形虫 基因工程疫苗 Toxoplasma gondii Genetic engineering vaccine
分类号 Q789 [生物学—分子生物学]
  • 相关文献

参考文献19

  • 1MH el Kouni. Adenosine metabolism in Toxoplasma gondii: potential targets for chemotherapy. Curr Pharm Des, 2007,13 (6) : 581 -597.
  • 2Jongert E, Roberts C W, Gargano N, et al. Vaccines against Toxoplasma gondii: challenges and opportunities. Mere Inst Oswaldo Cruz, 2009, 104(2) : 252 -266.
  • 3Bout D T, Mevelec M N, Velge-Roussel F, et al. Prospects for a human Toxoplasma vaccine. Curr Drug Targets Immune Endocr Metabol Disord, 2002, 2 ( 3 ) : 227 - 234.
  • 4Kasper L H, Bradley M S, Pfefferkorn E R, et al. Identification of stage-specific sporozoite antigens of Toxoplasma gondii by monoelonal antibodies. J Immunol, 1984, 132 : 443 - 449.
  • 5Partanen J, Braekeleer D, Diet R, et al. Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene. J Clin Microbiol, 1984,20(1) : 133 -135.
  • 6司进,汤俊明,赵松,殷旭仁,徐明,何伟,华万全,梁幼生,朱荫昌.刚地弓形虫RH株主要表面抗原1的原核表达和纯化及免疫反应性检测[J].中华检验医学杂志,2004,27(2):107-109. 被引量：5
  • 7Kim K, Bulow R, Kampmeier J, et al. ConformationaUy appropriate expression of the Toxoplasma gondii SAG1 (P30) in CHO cells. Infect Immun, 1994,62 : 203- 209.
  • 8Liu Q, Gao S, Jiang L, Shang L, et al. A recombinant pseudorabics virus expressing TgSAG1 protects against challenge with the virulent Toxoplasma gondii RH strain and pseudorabies in BALB/c mice. Microbes Infect, 2008, 10 (12,13) : 1355 - 1362.
  • 9Aline F, Bout D, Amigorena S, et al. Toxoplasma gondii antigenpulsed-dendritic cell-derived exosomes induce a protective immune response againsr T. gondii infection. Infect Immun, 2004, 72(7) : 4127 -4137.
  • 10Garcia J L, Navarro I T, Biazzono L, et al. Protective activity against oocyst shedding in cats vaccinated with crude rhoptry proteins of the Toxoplasma gondii by the intranasal route. Vet Parasitol, 2007, 145 (3,4) : 197 - 206.

二级参考文献12

  • 1Li-XinZhu JingLiu YeYe You-HuaXie Yu-YingKong Guang-DiLi YuanWang.A candidate DNA vaccine elicits HCV specific humoral and cellular immune responses[J].World Journal of Gastroenterology,2004,10(17):2488-2492. 被引量：12
  • 2张佃波,公茂庆,魏庆宽,李谨,黄炳成,刘克义.刚地弓形虫P30(SAG1)基因的克隆与表达[J].中国寄生虫病防治杂志,2005,18(2):92-95. 被引量：9
  • 3Angus CW, Klivington-Evans D, Dubey JP, et al. Immunization with a DNA plasmid encoding the SAG1 (p30) protein of Toxoplasma gondii is immunogenic and protective in rodents[J]. Infect Dis, 2000,181:317-324.
  • 4Saavedra R, Becerril MA, Dubeaux C, et al. Epitopes recognized by human T lymphocytes in the ROP2 protein antigen of Toxoplasma gondii[J]. Infect Immun, 1996,64:3858-3862.
  • 5Beckers CJ, Dubremetz JF, Mercereau PO, et al. The Toxoplasma gondii rhoptry protein ROP2 is inserted into the parasitophorous vacuole membrane surrounding the intracellular parasite and is exposed to the host cell cytoplasm[J]. Cell Biol, 1994,127:947-961.
  • 6Bunell BA, Morgan RA. Gene therapy for infectious diseases[J]. Clin Microbiol, 1998,11:42-56.
  • 7Alberto F, Alexandro R, Sergio O, et al. Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice[J]. Vaccine, 2003,21:1327-1335.
  • 8Gazzinelli RT, Wysocka M, Hayashi S, et al. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with T. gondii [J]. Immunol, 1994,153:2533-2543.
  • 9Coughlan SN, Saman E, Jacobs D, et al. Cellular and humoral immune responses to recombinant antigens in sheep infected with Toxoplasma gondii[J]. Parasite Immunol, 1995,17:465-468.
  • 10Leyva R, Herion P, Saavedra R, et al. Genetic immunization with plasmid DNA coding for the ROP2 protein of T. gondii[J]. Parasitol Res, 2001,87:70-79.

共引文献13

同被引文献14

  • 1McLeod R,Boyer K,Karrison T,et al.Outcome of treatment for con genital toxplasmosis,1981 2004:the national collaborative chicago based,congenital toxoplasmosis study[J].Clin Infect Dis,2006,42(10):1383-1394.
  • 2Tenter AM.Toxoplasma gondii in animals used for human consump tion[J].Mem Inst Oswaldo Cruz,2009,104(2):364-369.
  • 3Crowford J,Gmjic O,Bruie E,et al.Structural characterization ofthe bradyzoite surface antigen(BSR4)from Toxoplasma gondii,aunique addition to the surface antigen glycoprotein 1 related super family[J].J Biol Chem,2009,284(14):9192-9198.
  • 4Craver MP,Knoll LJ.Increased efficiency of homologous recombina tion in Toxoplasma gondii dense granule protein 3 demonstraes thatGRA3 is not necessary in cell culture but does contribute to virulence[J].Mol Biochem Parasitol,2007,153(2):149-157.
  • 5Beghetto E,Buffolano W,Spadoni A,et al.Use of an immunoglobu lin G avidity assay based on recombinant antigens for diagnosis ofprimary Toxoplasma gondii infection during pregnancy[J].J ChinMicroboil,2003,41(12):5414-5418.
  • 6崔玉玲 薛明福 何深一 等.刚地弓形虫复合基因疫苗、混合疫苗及多表位疫苗研究进展.国际医学寄生虫病杂志,2008,35(3):146-149.
  • 7杨培梁,李华,周晓红,彭鸿娟,吴焜,陈晓光.弓形虫多表位基因重组抗原在弓形虫免疫检测中的应用[J].热带医学杂志,2007,7(9):853-855. 被引量：8
  • 8李首庆,古钦民,杨广民,马寅芙.弓形虫SAG1、GRA2单基因疫苗及SAG1-GRA2复合基因疫苗的免疫效果观察[J].中国实验诊断学,2008,12(10):1219-1222. 被引量：4
  • 9李克生,杜惠芬,连晓雯.人群弓形虫感染及其检测方法的重要性[J].预防医学情报杂志,2009,25(3):215-218. 被引量：3
  • 10殷国荣,郝海霞.弓形虫病：食用肉类传播的风险及控制对策[J].国际医学寄生虫病杂志,2009,36(5):355-361. 被引量：2

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二级引证文献2

中国生物工程杂志
2009年 第11期

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