红曲桔霉素控制对策

The Strategy of Citrinin Production Control in Monascus

红曲的药用价值和保健功能日益引人关注,然而红曲中桔霉素的存在严重制约着红曲产品的开发,如何降低红曲桔霉素的含量是一个迫切需要解决的问题。概述了红曲桔霉素的毒性、生物合成途径及相关标准。并结合国内外研究进展,从发酵工艺、诱变育种、基因工程三个层面阐述了控制红曲桔霉素产生的对策,并对桔霉素今后的研究方向进行了展望。

Pepole pay more attention to the medicinal value and health function of Monascus day by day, however, the existence of citrinin restricted the further development of Monascus products heavily. How to ruduce the content of citrinin is a problem need to be solved urgently. Briefly introduced the toxicity, the biosynthetic pathway, and the relative standards of citrinin in monascus. According to the research progress on citrinin, the strategies of citrinin control were described from the three aspects of fermentation technology, mutation breeding, and genetic engineering. The expectation about the direction of citrinin in the future was also discussed.