期刊文献+

替米沙坦治疗糖尿病合并高血压疗效观察

原文传递
导出
摘要 目的研究替米沙坦对2型糖尿病合并高血压的患者血压以及代谢指标的控制效果。方法选择60例2型糖尿病合并高血压患者,给予替米沙坦80mg,1次/d口服,同时治疗糖尿病及其他并发症。结果治疗3个月后,血压、血浆胰岛素水平、血糖、HbA1c、血脂变化差异有统计学意义(P<0.05)。结论替米沙坦可明显改善2型糖尿病的代谢障碍,可能通过激活过氧化物酶体增殖物激活受体(γ(PPAR(γ)等多途径实现降压及降血糖的效果,适合于代谢综合征的治疗。
作者 周静林
出处 《中国煤炭工业医学杂志》 2009年第11期1702-1703,共2页 Chinese Journal of Coal Industry Medicine
  • 相关文献

参考文献10

  • 1姜先雁,王丽萍,史秀忠,杨瑛,马林茂,张红叶,刘献成,赵玉红.肥胖对青岛港职工高血压患病率的影响[J].中国煤炭工业医学杂志,2004,7(1):18-19. 被引量:3
  • 2魏华,郑建东.北京市朝阳门社区高血压流行情况及相关因素调查[J].疾病监测,2001,16(8):310-312. 被引量:8
  • 3霍勇,颜红兵,乌长生,等.美国冠心病诊断和治疗指南[M].2版.北京:中国环境科学出版社,2006:261.
  • 4刘尊永.糖尿病综合防治指南[M].北京:人民卫生出版社,2006:348.
  • 5陈清江,王瑞淦.替米沙坦治疗高血压临床研究进展[J].国外医学(老年医学分册),2004,25(5):225-228. 被引量:11
  • 6Theodore W, Kurtz, Michal Prawenec. Antidiabetic mechanisms of angiotensin- converting enzyme inhibitors and angiotensin Ⅱ receptor antagonists: beyond the rennin - angiotensin system[J]. Journal of Hypertension, 2004,22 (12) : 2253 - 2261.
  • 7Savage DB,Tan GD, AceriniCL, et al. Human metabolic syndrome resulting from dominant - negative mutations in the nuclear receptor peroxisome proliferator- activated receptor - γ[J]. Diabetes,2003,52:910 - 917.
  • 8Pershadsingh HA. Peroxisome proliferator - activated receptor-γ:therapeutic target for diseases beyond diabetes: Quo vadis[J]. Expert Opin Invest Drugs, 2004,13 : 215 - 228.
  • 9Berger J, Moller DE. The mechanisms of action of PPARs[J]. Annu Rev Med, 2002,53:409 - 435.
  • 10贺玉泉,杨萍,祝金明,李淑梅.PPAR-γ在兔动脉粥样硬化模型中的表达及替米沙坦的干预作用[J].中国实验诊断学,2007,11(4):533-536. 被引量:6

二级参考文献31

  • 1魏钧伯,魏盟,陈绍良,蔡绳.外周血ox-LDL浓度与血脂状态关系的研究[J].实用医技杂志,2004,11(12B):2627-2629. 被引量:2
  • 2武阳丰,周北凡,李莹,张红叶,张新华,杨军,陶寿淇.体重指数与心血管病几大生物学危险因素个体聚集性的关系[J].中国慢性病预防与控制,1996,4(5):208-210. 被引量:59
  • 3Amra SS, DongreN, Ballary C et al. Comparison of the efficacy, safety and tolerability of telmisartan with losartan in Indian patients with mild to moderate hypertension: a pilot study. J Indian Med Assoe, 2003; 101 (5): 327~328
  • 4Lacourciere Y, Gil- Extremera B, Mueller O et al. Efficacy and tolerability of fixed- dose combinations of telmisartan plus HCTZ compared with losartan plus HCTZ in patients with essential hypertension. Int J Clin Pr act, 2003; 57 (4): 273~279
  • 5Stergiou GS, Efstathiou SP, Roussias LG et al. Blood pressure-and pulse pressurelowering effects, trough: peak ratio and smoothness index of telmisartan compared with lisinoril. J Cardiovase Pharmacol, 2003; 42 (4): 491~496
  • 6Galzerano D, Tammaro P, Cerciello A et al. Freehand three-dimensional echocardiographic evaluation of the effect of telmisartan compared with hydrochlorothiazide on left ventricular mass in hypertensive patients with mild - to - moderate hypertension: a m
  • 7White WB, Lacourciere Y, Davidai G. Effects of the angiotensin Ⅱ receptor blockers to Imisartan versus valsartan on the circadian variation of blood pressure; impact on the early morning period. Am J Hypertens, 2004; 17 (4): 347~353
  • 8Smith DH. Treatment of hypertension with an angiotensin Ⅱ-receptorantagonist compared with an angiotensin - converting enzyme inhibitor: a review of clinical studies of telmisartan and enalaprill. ClinTher, 2002; 24 (10): 1484~501
  • 9Dunselman PH. Replacement of angiotensin oonverting enzyme inhibition (REPLACE) investigators. Effects of the replacement of the angiotensin converting enzyme inhibitor enalapril by the angiotensin Ⅱ receptor blocker telmisartan in patients with congesti
  • 10Kostis JB. Treatment of hypertension in older patients: an updated look at the role of calcium antagonists. Am J Geriatr Cardiol, 2003; 12 (5): 319-327

共引文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部