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Ghrelin对莎能奶山羊下丘脑GHRH和SS mRNA表达的调节 被引量：1

Effect of Ghrelin on the Expression of GHRH and SS mRNA in the Hypothalamus in Saanen Goats
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摘要 为探讨ghrelin对奶山羊下丘脑促生长激素释放激素(GHRH)、生长抑素(SS)mRNA表达的影响,10只青春前期莎能母奶山羊随机分为2组,试验组和对照组,每组5只。试验组羊经颈静脉注入一定量的ghrelin(3.0μg/kg)3 h后宰杀,用RT-PCR方法检测ghrelin对下丘脑GHRH、SS mRNA表达的影响。结果表明试验组羊下丘脑GHRH mRNA的表达显著上调(P<0.01);下丘脑中SS mRNA的表达也显著升高(P<0.05)。表明ghrelin在下丘脑水平上对GHRH和SS mRNA的表达具有上调作用,提示ghrelin可能通过GHRH途径调节垂体GH的分泌。 To investigate the effect of ghrelin on expression of GHRH and SS mRNA in the hypothalamus after injection of ghrelin through vein injection in goats,Ten Saanen goats were randomly divided into 2 groups： experiment group and control group.The expression of GHRH and SS mRNA was studied with relative quantity RT-PCR after injection of ghrelin in goats.The results showed that ghrelin could significantly up regulated the expression of GHRH mRNA in the hypothalamus（P〈0.01）,and a significant change for the abundance of SS mRNA expression was observed in the hypothalamus after injecting ghrelin（P〈0.05）.The above studies suggested that ghrelin may be involved in regulating the expression of GHRH and SS mRNA in the hypothalamus,it provided the physiological data for ghrelin in regulating the expression of GH.
作者 张文龙
机构地区 西北农林科技大学动物医学院
出处 《动物医学进展》 CSCD 北大核心 2009年第11期46-50,共5页 Progress In Veterinary Medicine
基金 西北农林科技大学人才基金(01140502) 中国博士后科学基金面上项目(20090451402)
关键词 GHRELIN 促生长激素释放激素 SS 莎能奶山羊 ghrelin GHRH SS Saanen goat
分类号 S858.27 [农业科学—临床兽医学]
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参考文献16

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二级参考文献23

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共引文献15

同被引文献31

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动物医学进展
2009年 第11期

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