我国猪瘟病毒分子流行病学研究进展

Progress on Molecular Epidemiology of Classical swine fever virus in China

猪瘟是严重危害我国养猪业的烈性传染病。近年来,我国在猪瘟病毒的分子流行病学研究方面取得了较大进展。基于E2、E0基因对我国猪瘟病毒流行毒株分群显示,基因Ⅱ群占主导地位,基因Ⅰ群次之,没有发现基因Ⅲ群。我国多数猪瘟病毒流行毒株E2基因越来越向远离HCLV株的方向变异,这一趋势可能会对我国以疫苗免疫为主的防控策略构成威胁。流行毒株E0基因与疫苗株相比发生了一定程度的变异,但在RNase活性有关的关键位点上高度保守,没有发现变异位点。

Classical swine fever is a serious infectious diseases which endangers pig farming industry in our country.In recent years,the molecular epidemiological studies of classical swine fever virus in China made great progress.Based on the E2 and E0 genes of epidemic classical swine fever virus strains,the gene Ⅱ is dominant group,followed by gene Ⅰ group,no gene Ⅲ group.Comprehensive sequence analysis reported in the literature showed that the direction of variation of the majority of epidemic classical swine fever virus E2 gene stayed away from HCLV,this trend may be a threat in China based vaccine in the prevention and control strategies,it should be close attention.Epidemic strain E0 gene,compared with the vaccine strain E0 gene,occurred in a certain degree of variability,but the key sites of RNase activity were highly conservative,and did not find mutation.