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缺血缺氧性脑损伤中有关缺氧诱导因子-1的研究进展 被引量：2

Hypoxia-inducible factor-1 in hypoxic-ischemic brain injury： recent advances
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摘要 缺氧诱导因子-1（hypoxia-inducible factor 1，HIF-1）由Semenza于1992年发现，为连接在红细胞生成素（erythropoietin，EPO）基因低氧反应元件上的一个核因子。
作者 林洁 余勤 刘丽珍
机构地区 浙江中医药大学生物工程学院 浙江大学医学院附属第一医院骨髓移植中心
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2009年第11期1172-1174,共3页 Chinese Journal of Neuromedicine
基金 国家自然科学基金（30940028） 浙江省自然科学基金（Y2080787） 浙江省卫生厅课题（2006A092）
关键词 缺氧诱导因子-1 缺血缺氧 脑 Hypoxia-inducible factor 1 Hypoxic- ischemia Brain
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献26

  • 1Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation [J]. Mol Cell Biol, 1992, 12(12): 5447-5454.
  • 2Semenza GL. Expression ofhyposia-inducible factor 1: mechanisms and consequences [J]. Biochem Pharmacol, 2000, 59(1): 47-53.
  • 3Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1 [J]. Biochem Biophys Res Commun, 1996, 225 (2): 485-488.
  • 4Kumral A, Baskin H, Yesilirmak DC, et al. Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain [J]. Neonatology, 2007, 92 (4): 269-278.
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  • 6Semenza GL. HIF-1 and human disease: one highly in-volved factor [J]. Genes & development, 2000, 14 (16): 1983-1991.
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  • 8Minet E, Michel G, Mottet D, et al. Transduction pathways involved in hypoxia-inducible Factor-1 phosphorylation and activation[J]. Free Radic Biol Med, 2001, 31 (7): 847- 855.
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  • 10亢登峰,刘扬,王英元,王亚方.HIF-1α、IGF-1表达与脑挫伤时间的相关性[J].法医学杂志,2007,23(3):174-176. 被引量：2

二级参考文献42

  • 1吴海琴,张蓓,展淑琴,张桂莲,张茹,袁海峰.大鼠前脑缺血诱导HIF-1α、EPO表达的研究[J].卒中与神经疾病,2006,13(1):34-36. 被引量：8
  • 2[2]Marti HJ,Bernaudat M,Bellail A,et a1.Hypoxia-induced vascular endothelial growth factor expression precedes neovascularizatton after cerebral ischemia[J].Am J Patho1,2000,156(3):965-976.
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  • 7[7]Xuan YT,Tang XL,Qin Y,et a1.Biphasic response ofcardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits[J].Am J Physiol,2000,279(5):2360-2371.
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共引文献11

同被引文献22

  • 1袁桂清.果糖二磷酸钠对各种缺血缺氧损伤的保护和治疗效果显著[J].中华医学信息导报,2002,17(15):5-5. 被引量：1
  • 2卢洪流.中英对照GCS评分[J].中华神经医学杂志,2005,4(5):497-497. 被引量：64
  • 3王文海.果糖二磷酸钠的作用机制与临床应用[J].上海医药,1996(7):22-23. 被引量：7
  • 4Yang MH, Wu MZ, Chiou SH, et al. Direct regulation of TWIST by HIF-I alpha promotes metastasis[J]. Nat Cell Biol, 2008, 10(3): 295-305.
  • 5王代旭,黄元奎,牛红泉,等.摩米泞布刈胶质瘤U251细胞株放射敏感性影响的实验研究[J]实川医学杂志,2008,24(5):716-719.
  • 6Du R, Lu KV, Petritsch C, et al. H1F alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion [J]. Caner Cell, 2008, 13 (3): 206-220.
  • 7Sher 1, Adham SA, Petrik J, et al. Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis [J]. lnt J Cancer, 2009, 124(3): 553-561.
  • 8Li GH, Chert ZT, Hu YD, et al. Autocrine factors sustain glioblastoma stem cell self-renewal[J]. Oncol Rep, 2009, 2t (2): 419-424.
  • 9Kaur C, Sivakumar V, Foulds WS, el al. Cellular and vascular changes in the retina of neonatal rats after an acute exposure to hypoxia [J]. Invest Ophthalmol Vis Sci, 2009, 50(11): 5364-5374.
  • 10李明武,牛朝诗.脑肿瘤干细胞的分布与肿瘤微血管的相关性[J].中华医学杂志,2010,90(5):305-309. 被引量：6

引证文献2

二级引证文献9

中华神经医学杂志
2009年 第11期

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