摘要
SAPHO综合征是一种少见的慢性无菌性炎症性疾病，主要表现为滑膜炎、痤疮、脓疱病、骨肥厚和骨炎。本病具有遗传易感性，并可能与痤疮丙酸杆菌等某些低毒性微生物感染有关。非甾体类抗炎药、抗生素和改善疾病症状的抗风湿药物等传统药物疗效欠佳。近年来用二磷酸盐类钙代谢调节剂和抗肿瘤坏死因子-α生物制剂治疗某些患者取得较满意疗效。
SAPHO syndrome is a kind of rare chronic aseptic inflammation characterized by synovitis, acne, pustulosis, hyperostosis and osteitis. It has genetic predisposition and is associated with hypotoxic microorganism infection. Non-steroidal antiinflammatory drugs （NSAIDs）, antibiotics and disease modifying antirheumatic drugs （DMARDs） have unsatisfactory therapeutic effect on this disease. In recent years, bisphosphonates and anti-tumor necrosis factor α biologic agents have been applied to the treatment of this disease and shown promising efficacy.
出处
《国际皮肤性病学杂志》
2009年第6期376-378,共3页
International Journal of Dermatology and Venereology
关键词
获得性骨肥大综合征
研究
Acquired hyperostosis syndrome
Research
