冠脉支架植入对冠心病患者血清IL-18及CRP水平的影响

Effects of intracoronary stent on serum IL-18 and CRP levels of patients with coronary heart disease

目的:观察冠心病患者冠脉支架植入前后,血清白细胞介素18(IL-18)及C反应蛋白(CRP)水平的变化。方法:冠心病患者30例在冠脉支架植入前后,分别于空腹12 h后清晨采集静脉血5 ml。采用双抗体夹心ELISA法测定外周血清IL-18的浓度,选用全自动生化分析仪测定CRP的含量,并比较冠脉支架植入术前后IL-18和CRP水平的变化。结果:冠脉支架植入术前,血清IL-18的平均浓度为(1.42±0.47)ng/L,术后平均浓度为(2.64±0.54)ng/L,两者比较差异具有显著性(P<0.01)。术前血清CRP的平均浓度为(5.26±1.28)mg/L,术后平均浓度为(11.86±1.61)mg/L,两者比较差异也具有显著性(P<0.01)。结论:冠脉支架植入术对血清IL-18及CRP的水平有明显影响。

AIM： To observe the changes of the levels of interleukin-18 （IL-18） and C-reactive protein （CRP） before and after intracoronary stent in patients with coronary heart disease （CHD）. METHODS： Five ml blood was collected during the early morning from peripheral vein before and after intracoronary stent treatment in 30 CHD patients. IL-18 was detected with ELISA, and CRP was measured with an automatic biochemical analyzer. RESULTS： The concentration of IL-18 was significantly elevated after intracoronary stent [（2.64±0.54）ng/L vs. （1.42±0.47）ng/L, P〈0.01]. The concentration of CRP was also significantly elevated after intracoronary stent [（11.86±1.61） mg/L vs. （5.26±1.28） mg/L, P〈0.01]. CONCLUSION： Concentrations of IL-18 and CRP in CHD patients are significantly elevated after intracoronary stent.