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YB-1蛋白在大鼠系膜增殖性肾小球肾炎及体外培养大鼠肾小球系膜细胞中的表达及其意义 被引量:2

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摘要 肾小球系膜细胞增殖是系膜增殖性肾小球肾炎(MsPGN)的常见病理特征,活化后的系膜细胞可分泌多种细胞因子,导致系膜细胞增殖及细胞外基质增生。YB-1可作为细胞周期时期专一性转录因子,通过促进cyclinA、cyclinB1基因的表达来控制细胞增殖进程,提示YB-1在细胞增殖中可能起重要作用:本研究通过建立MsPGN模型和体外培养系膜细胞增殖模型,在整体和细胞水平观察YB-1表达与系膜细胞增殖,ERK信号通路的关系:
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2009年第11期875-877,共3页 Chinese Journal of Nephrology
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  • 1Jurchott K, Bergmann S, Stein U, et al. YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression. J Binl Chem. 2003, 278: 27988- 27996.
  • 2Ishizaki M, Masuda Y, Fukuda Y, et al. Experimental mesangioproliferative glomerulonephritis in rats induced by intravenous administration of anti-thymocyte serum. Acta Palhol Japonica, 1986, 36: 1191-1203.
  • 3李晓玫,唐嘉薇,李彪,侯平.丝裂素活化蛋白激酶信号转导途径对血小板源生长因子所致鼠肾系膜细胞表型转化的调控作用[J].中华肾脏病杂志,2000,16(6):347-351. 被引量:15
  • 4Coles LS, Lambrusco L, Burrows J, et al. Phosphorylation ofcold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoter. FEBS Letters, 2005, 579: 5372-5378.

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  • 1Yokota S. Mizoribine: mode of action and effects in clinical use[J]. Pediatr Int,2002 ;44 ( 2 ) : 196-198.
  • 2Raffetseder U, Rauen T, Boor P et al. Extracellular YB-1 blockade in experimental nephritis upregulates Notch-3 receptor expression and signaling [ J ]. Nephron Exp Nephrol, 2011 ; 118 (4) : 100 - 108.
  • 3Kawaguchi A, Matsumoto K, Nagata K et al. YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules [J]. J Virol, 2012; 86(20):11086-11095.
  • 4Liu S, Xie Y, Lv Y et al. A novel target of mizoribine inhibiting mesangial cell proliferation: S phase kinase-associated protein 2 [ J ]. Am J Nephrol, 2010 ;32 (5) :447-455.
  • 5Di Costanzo A, Troiano A, di Martino O et al. The p63 protein isoform Np63α modulates Y-box binding protein 1 in its subcellular distribution and regulation of cell survival and motility genes[ J]. J Biol Chem, 2012 ; 287 (36) :30170-30180.
  • 6Das S, Chattopadhyay R, Bhakat K K et al. Stimulation of NEIL2 - mediated oxidized base excision repair via YB-I interaction during oxidative stress [ J ]. J Biol Chem, 2007 ;282 ( 39 ) : 28474 -28484.
  • 7Rauen T,Raffetseder U, Frye B C et al. YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation [ J ]. J Biol Chem, 2009 ; 284 ( 39 ) :26928-26940.
  • 8Zhu L,Zhang Q, Shi S, et al. Synergistic effect of mesan- gial cell-induced CXCL1 and TGF-betal in promoting podocyte loss in IgA nephropathy [J]. PLoS One,2013,8 (8) : e73425.
  • 9Eliseeva IA,Kim ER,Guryanov SG,et al. Y-box-binding protein I(YB-1) and its functions[Jl. Biochemistry, 2011,76(13) : 1402-1433.
  • 10Huang XZ,Wen D,Zhang M,et al. Sirtl activation ame- liorates renal fibrosis by inhibiting the TGF-beta/Smad3 pathway[J]. J Cell Biochem,2014, 115(5) :996-1005.

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