细胞周期调控相关蛋白Cyclin D1、CDK4和pRb在新疆维吾尔族妇女宫颈癌中的表达及意义

Expression and Significance of CyclinD1,CDK4 and pRb in Cervical Carcinomas in Xinjiang Uigur Women

目的探讨细胞周期调控相关蛋白Cyclin D1、CDK4和pRb磷酸化状态在新疆维吾尔族妇女宫颈癌(简称维族)中表达及其意义。方法应用免疫组织化学方法检测64例维族宫颈癌及43例维族正常宫颈组织中Cyclin D1、CDK4表达和pRb磷酸化状态。结果Cyclin D1和CDK4在宫颈癌组中阳性率分别为70%、87%,与正常宫颈组相比,差异有统计学意义(P<0.05),pRb磷酸化在两组中差异有统计学意义(P<0.01)。结论Cyclin D1与CDK4蛋白的高表达及pRb高磷酸化可能与维族宫颈癌发生发展有关。

Objective To study the expression and tsignificance of Cyclin D1, CDK4 and the levels of phosphorylated pRb in cervical carcinoma in Xinjiang Uigur Women. Methods The expression of Cyclin D1,CDK4 protein and phosphorylation status of pRb were detected by immunohistochemistry in 64 cervical carcinoma tissues and 43 normal cervical tissues. Results In cervical carcinomas, the positive rate of Cyclin D1 and CDK4 were 70% and 87%, respectively. There were significant differences of CyclinD1 and CDK4 protein compared with normal cervical tissues（P〈0.01）. Phosphorylation status of pRb had significant difference in the two groups （P〈0.01）. Conclusion The overexpression of Cyclin D1 and CDK4 and the hyperphosphorylation of pRb may have relationship with carcinogenesis and the development of cervical cancer in Xinjiang Uigur Women.