人类RHD基因及RhD蛋白的研究进展
摘要
人类RHD基因及RhD蛋白多态性均较强,在输血医学中的重要性仅次于ABO血型抗原。RhD蛋白具有很强的免疫原性,能够引起新生儿溶血病和溶血性输血反应。RhD蛋白存在多种变异体,主要包括弱D、不完全D和Del型。本文就人类RHD基因、RhD蛋白及其变异体的相关内容作一综述。
出处
《国际输血及血液学杂志》
CAS
2009年第6期527-529,共3页
International Journal of Blood Transfusion and Hematology
参考文献21
-
1Matassi G, Cherif-Zahar B, Pesole G, et al. The members of the RH gene family(RH50 and RH30)followed different evolutionary pathways. J Mol Evol, 1999, 48(2) :151-159.
-
2Wagner FF, Fleqel WA. RHD gene deletion occurred in the Rhesus box. Blood, 2000, 95(12) :3662-3668.
-
3Maaskant-van Wijk PA, Faas BH, de Ruijter JA, et al. Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons. Transfusion, 1998, 38 ( 11- 12): 1015-1021.
-
4Blumenfeld OO, Patnaik SK. Allelic genes of blood group antigens:a source of human mutations and cSNPs documented in the Blood Broup Antigen Gene Mutation Database. Hum Mutat, 2004, 23(1):8-16.
-
5Westhoff CM. The Rh blood group system in review: a new face for the next decade. Transfusion, 2004, 44(11):1663-1673.
-
6Westhoff CM, Wylie DE. Transport characteristics of mammalian Rh and Rh glyco-proteins express-ed in heterologous systems. Transfus Clin Biol, 2006, 13(1-2):132-138.
-
7Flegel WA, Wagner FF. Molecular biology of partial D and weak D:implications for blood bank practice. Clin Lab, 2002, 48 (1): 53-59.
-
8Flegel WA, Wangner FF. Molecular genetics of RH. Vox Sang, 2000, 78(suppl 2) :109-115.
-
9Wagner FF, Frohmajer A, Flegel WA. RHD positive haplotypes in D negative Europeans. BMC Genet, 2001, 2:10.
-
10Cowley NM, Saul A, Hyland CA. RHD gene mutation and weak D phenutype:an Australian blood donor study. Vox Sang, 2000, 79(4) :251-252.
二级参考文献47
-
1邵超鹏,苏宇清,孔生生.Rh血型D抗原检测方法讨论[J].华南国防医学杂志,2001,15(1):50-51. 被引量:6
-
2徐群,张世训,张建业,司桂玲,宋永红,王玫,李京,王潍,聂向民.中国汉族人群RHCE和RHD基因结构研究[J].临床输血与检验,2000,2(1):1-4. 被引量:5
-
3Shao CP, Maas JH, Su YQ, et al. Molecular background of Rh Dpositive, D-negative, E# and weak D^el phenotypes in Chinese. Vox Sang,2002,83(2) : 156.
-
4Flegel WA, Wagner FF. Molecular genetics of RH. Vox Sang,2000,78(Suppl 2) : 109.
-
5Legler TJ,Maas JH,Kohler M,et al. RHD sequencing: a new tool for decision making on transfusion therapy and provision of Rh prophylaxis. Transfus Med,2001,11(5) :383.
-
6Wagner FF,Gassner C, Muller TH, et al. Molecular basis of weak D phenotypes. Blood, 1999,93( 1 ) ~ 385.
-
7Legler TJ, Wiemann V, Ohto H, et al. D(Va) category phenotype and genotype in Japanese families. Vox Sang,2000,78(3) : 194.
-
8Chang JG,Wang JC, Yang TY,et al. Human RhD^el is caused by a deletion of 1,013 bp between introns 8 and 9 including exon 9 of RHD gene.Blood, 1998,92(7) :2602.
-
9Perco P,Shao CP,Mayr WR,et al. Three different methods to test for RhD zygosity: description of altered downstream Rhesus Boxes and a new weak D type.Transfusion,2003,43(3) :335-339.
-
10Chiu RW, Murphy MF, Fidler C, et al. Determination of RhD zygosity: comparison of a double amplification refractory mutation system approach and a multiplex real-time quantitative PCR approach. Clln Cham,2001,47(4) :667.
共引文献38
-
1周华友,兰炯采.人类Rh血型系统研究进展[J].中国输血杂志,2004,17(3):211-214. 被引量:38
-
2周华友,兰炯采,王晓珠,樊红,孟庆宝,张印则,王从容.人RHD基因结构研究及意义[J].第四军医大学学报,2004,25(18):1659-1662. 被引量:2
-
3郭永芳.用PCR技术检测RhD(-)个体RHD基因的国内文献分析[J].临床检验杂志,2005,23(1):73-74. 被引量:2
-
4曾劲峰,李活,张红,马兰,聂冬梅,许晓绚.酶标仪快速检测Rh-D阴性血型的方法研究[J].国外医学(临床生物化学与检验学分册),2005,26(4):199-200.
-
5王晓珠,兰炯采,吴绪华,周华友,刘维佳,刘丹,齐村生,曾凤芹,杜克清.Rh弱D及Del样本的检测研究[J].中国实验血液学杂志,2005,13(3):509-511. 被引量:23
-
6周华友,白旭华,张印则,王从容,曹琼,兰炯采.中国汉族和维吾尔族RHD基因结构的比较研究[J].中华医学遗传学杂志,2006,23(2):151-155. 被引量:11
-
7蔡玲君,丁权,陈文仙,郭兆富,和苗,陈玲.云南地区RhD阴性个体RHD基因研究[J].中国输血杂志,2006,19(6):452-453. 被引量:21
-
8朱奕,薛俭成.Rh弱D抗原的临床检测意义[J].国际检验医学杂志,2007,28(2):166-167. 被引量:7
-
9蔡玲君,陈文仙,丁权,和苗,陈玲.89例Rh阴性血清学调查分析[J].昆明医学院学报,2007,28(5):134-135.
-
10周丹,熊文,张艳芳,邵超鹏.弱D15红细胞膜D抗原表位测定[J].中国输血杂志,2009,22(1):32-33. 被引量:14
-
1吴凡,张超,庄乃保,李大成,周丹,苏宇清,梁延连,徐华,周华友,张印则.可溶性RhD抗原检测方法的建立[J].中国输血杂志,2013,26(10):970-972. 被引量:1
-
2严力行,傅启华.Rh血型的分子生物学[J].国外医学(输血及血液学分册),1995,18(6):366-369. 被引量:3
-
3马春平,范业宁,张东红,吕扬,赵佳琪,赵臣.ABO血型抗原与感染性疾病的相关性[J].吉林医药学院学报,2017,38(1):49-51. 被引量:3
-
4熊文,邵超鹏,李雪梅,周一炎.Rh血型DEL表型RhD蛋白表达的研究[J].中华医学杂志,2006,86(2):128-132. 被引量:8
-
5相丽欣,陈曦阳,李忠俊,张艳,冉茜.白血病患者ABO血型抗原病理变异5例[J].中国输血杂志,2011,24(10):894-895. 被引量:4
-
6张印则,周丹,吴凡,苏宇清,梁延连,李大成,徐华,周华友.基于RhD蛋白Aptamer筛选技术的随机ssDNA次级文库制备条件的优化[J].中国输血杂志,2014,27(12):1293-1296. 被引量:2
-
7刘亚庆,刘长利,苗天红.Del血型研究进展[J].北京医学,2010,32(11):930-931. 被引量:1
-
8如何理解ABO血型抗原与输血的关系?[J].护士进修杂志,2007,22(10):869-869.
-
9屈林,李景和,刘凤霞.ABO血型抗原减弱所致疑难血型的原因分析及鉴定方法[J].中国输血杂志,2010,23(9):706-708. 被引量:31
-
10聂益军.恶性疾病导致ABO血型抗原或抗体减弱的讨论[J].检验医学与临床,2014,11(1):66-68. 被引量:9