CT导向下^(125)Ⅰ粒子组织间种植治疗头颈部肿瘤的临床研究

The Clinic Research of I Seeds for Malignan Tumor at the Head and Neck by CT-guided.

目的探讨CT引导下放射性^(125)Ⅰ组织间种植治疗头颈部恶性肿瘤的可行性。方法搜集整理我院2006年6月～2008年12月,对26例头颈部癌术后或放化疗后复发或转移患者行植放射性^(125)Ⅰ组织间种植治疗患者的临床资料。结果 26例均顺利完成手术,每例种植粒子12～54颗,中位数23颗。术后未发生出血、感染、粒子移位等严重并发症。28例随访3～24个月,平均16个月,局部控制率术后3个月为54%(14/26),6个月72%(18/25),12个月47%(11/23),2年37%(6/16)。结论放射性^(125)Ⅰ粒子种植治疗头颈部肿瘤是一种安全、有效、可行的治疗方法,其近期疗效值得肯定。

Objective To evaluate the feasibility of interstitial implantation of ^125I seeds for malignant tumor at the Head and Neck. Methods From Oct 2006 to Oct 2008,26 patients received interstitial implantation of ^125I seeds in our hospital because of recurrent or metastatic malignant tumors at the head or neck after surgery or chemotherapy, ^125I seeds were implanted into the tumor tissues under guidance of CT. Results The operation was completed in all the patients. A median of 23 seeds （ 12 - 54） were implanted in each case. No complications, such as hemorrhage,infection,or seed migration, occurred in the patients. The patients were followed up for 3 -24 months. During the period, the rate of local control was 54 % （15/28） at 3 months, 72% （18/25 ）at 6 months ,47% （11/23 ）at 12 months, and 37% （6/16） at 2 years. Conclusion Interstitial implantation of ^125I seeds is feasible for ecurrent or metastatic tumor at the head or neck with a good short- term outcome.