甲型H1N1流感二例报告并文献复习

Influenza A H1N1 Virus:A report of 2 cases and a literature review

目的提高对甲型H1N1流感的认识以及探讨中西医结合治疗的疗效。方法结合2例甲型H1N1流感患者的临床资料进行文献复习,并对甲型H1N1流感并发白细胞变化、肝肾功能异常进行分析。结果2例患者入院前均有发热症状,体温38.0℃以上,2次鼻咽拭子甲型H1N1流感病毒逆转录-聚合酶链反应(RT-PCR)核酸检测均为阳性,诊断为甲型H1N1流感。入院后给予盐酸奥司他韦抗病毒治疗,以及中药和对症治疗。体温正常第4天,完成5 d的抗病毒疗程后第1天和第2天开始出现甲型H1N1流感病毒核酸检测阴性。治疗过程中均有白细胞异常、淋巴细胞的变化和肾功能异常。甲型H1N1流感病毒核酸检测阳性持续5～7 d从发病到恢复。结论甲型H1N1流感并发症较轻,中西医结合治疗效果明显。

Objective To improve the understanding of influenza A H1N1 virus and explore the therapeutic effect of combining treatment of traditional Chinese medicine and western medicine. Methods Two cases of influenza A H1N1 virus were reported, and the literature was reviewed. The leucocyte changes and the functions of the liver and kidney were discussed. Results Two cases were admitted to hospital because of fever, The temperature on admission was above 38℃. The detection of influenza A H1N1 virus of the swabs of nose and throat were positive twice by RT-PCR. The diagnosis of imported influenza A H1N1 virus was made. The two cases were received anti-virus therapy with oseltamivir, and herbs as well as symptomatic treatment. The temperature returned to normal after two-day therapy. The nucleic acid assay of influenza A H1N1 virus showed negative by RT-PCR the first and second day after 4-day normal temperature and 5-day antivirus therapy. The two cases had granulocytopenia, lymphocytic change and renal dysfunction during the period of therapy. The positive assay of influenza A H1N1 virus lasted for five to seven days from onset to recovery. Conclusion The complication of influenza A H1N1 virus is mild. The therapeutic efficacy of combining treatment of traditional Chinese medicine and western medicine is obvious.