摘要
目的:检测细胞因子IL-4与约塔辛(eotaxin)在慢性荨麻疹(CU)患者皮肤组织中的表达。方法:采用免疫组织化学染色方法检测24例CU患者和12例健康对照皮肤组织中IL-4与eotaxin的表达。结果:CU患者皮损组织IL-4和eotaxin的表达均高于健康对照(P<0.001);患者正常皮肤组织eotaxin的表达显著高于健康对照(P<0.01)。结论:迟发相变态反应可能参与慢性荨麻疹的发病环节。
Objective： To determine the expression of IL - 4 and eotaxin in patients with chronic urticaria （CU）. Methods： Immunohistochemical staining was used to detect the expression of IL - 4 and eo ＇taxin in 24 CU and 12 normal controls. Results： The expression of IL - 4 and eotaxin in lesions was significantly higher in CU patients than unaffected skin of patients and normal controls （ P 〈 0. 001 ）. There was no significant difference in the expression of IL - 4 between the unaffected skin and the normal controls, but the eotaxin was significantly higher in unaffected skin of patients. Conclusion： The late - phase allergic reactions may play an important role in the pathogenesis of chronic urticaria.
出处
《中国麻风皮肤病杂志》
2009年第11期803-805,共3页
China Journal of Leprosy and Skin Diseases
