期刊文献+

过敏性紫癜患者外周血白细胞B7-H1分子的表达 被引量:2

下载PDF
导出
摘要 应用荧光抗体染色技术经流式细胞仪检测36例过敏性紫癜(AP)患者和24例正常对照者外周血白细胞表面的B7-H1分子的表达水平,AP患者组外周血单核细胞B7-H1表达水平显著高于正常对照组(t=3.62,P=0.001);在淋巴细胞和粒细胞表面,患者组和对照组B7-H1的表达无显著差别(P>0.05);肾累及患者单核细胞、淋巴细胞及粒细胞的B7-H1的表达水平均显著高于非肾累及患者(t=3.05,2.25,4.792;P=0.004,0.031,0.002)。AP患者外周血单核细胞表面B7-H1表达异常可能与AP发病机制有关。
出处 《中国麻风皮肤病杂志》 2009年第11期818-820,共3页 China Journal of Leprosy and Skin Diseases
基金 滨州医学院科技计划(BY2007KJ38)
  • 相关文献

参考文献11

  • 1Mills JA, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Henoch - Schonlein purpura. Arthritis Rheum 1990 ; 33 (8) : 1114 - 1121.
  • 2中华医学会儿科学分会肾脏病学组.紫癜性肾炎的诊断与治疗(草案)[J].中华儿科杂志,2001,39(12):748-748.
  • 3李文斌,陈凤琴,刘泽英,陈莉,王英荣,薄慕琴,尹娜.过敏性紫癜患儿Th细胞亚群及免疫球蛋白状态的研究[J].中国小儿血液与肿瘤杂志,2006,11(1):19-22. 被引量:39
  • 4丁艳,刘玲,董宗祈.过敏性紫癜肾炎患儿血清细胞因子水平变化及意义[J].临床儿科杂志,2005,23(9):643-645. 被引量:27
  • 5Tamura H, Dong H, Zhu G, et al. B7 - H1 costimutation preferentially enhances CD28- independent T- helper cell function. Blood 2001 ;97(6) : 1809 - 1816.
  • 6Loke P, Allison JP. PD - L1 and PD- L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci USA 2003; 100(9): 5336 - 5341.
  • 7冯爱平,王菲,吴艳,连昕,陈善娟,刘志香.SLE患者外周血白细胞B7-H1分子的表达[J].中华皮肤科杂志,2007,40(4):221-223. 被引量:3
  • 8Wiendl H, Mitsdoerffer M, Schneider D, et al. Human muscle cells express a B7- related molecule, B7- H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies. FASEB J 2003; 17(13) : 1892 - 1894.
  • 9Youngnak P, Kozono Y, Kozono H, et al. Differential binding properties of B7 - H1 and B7 - DC to programmed death - 1. Biochem Biophys Res Commun 2003 ; 307 (3) : 672 - 677.
  • 10Guifang C, Amon K, Enedina ML, et al. PD- 1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4 ^+ T cells. Cell Immunol 2004 ; 230(2) : 89 - 98.

二级参考文献19

  • 1Stancovski I, Baltimore D.NF-kappaB activation: the I kappaB kinase revealed? Cell, 1997, 91( 3): 299-302.
  • 2Shinichi K, Masashi S, Futoshi T, et al.Evidence that de novo protein synthesis is dispensable for anti-apoptotic effects of NF-KB. Oncogene, 2000, 19( 16): 2233-2239.
  • 3Cabellos C, Macintyre DE, Forrest M, et al.Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space.J Clin Invest, 1992, 90( 2): 612-618.
  • 4Sattles J, Evans M, Miller RW, et al.T cell rescue of monocytes from apoptosis: role of the CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity.J Leukocyte Biol, 1996, 60( 6): 651-666.
  • 5Mills JA,Michel BA,Bloch DA,et al.The American College of Rheumatology 1990 criteria for the classification of Henoch - Schonlein purpura.Arthritis Rheum,1990;38(8) :1114-1121.
  • 6Wiereinski R,Zoch -Zwierz W,Wasilewska A,et al.Lymphocyte subpopulations of peripheral blood in children with Henoch - Schonlein purpura and IgA nephropathy.Polmerkuriusz lek,2001; 10 (58):244- 246
  • 7Egan CA,Taylor TB ,Meyer LJ,et al.IgA1 is the major IgA subclass in cutaneous blood vessels in Henoch - Schonlein purpura.Br J Dermatol,1999; 141 (5) :859 -62.
  • 8Dong H, Zhu G, Tamada K, et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med, 1999, 5(12): 1365-1369.
  • 9Ding H, Wu X, Gao W. PD-L1 is expressed by human renal tubular epithelial cells and suppresses T cell cytokine synthesis. Clin Immunol, 2005, 115(2): 184-191.
  • 10Bombardier C, Gladman DD, Urowitz MB, et al. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum, 1992, 35(6): 630-640.

共引文献121

同被引文献11

引证文献2

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部