原发性胆囊癌基因研究现状

Advances in research of primary gallbladder carcinoma at the genetic level

原发性胆囊癌是常见的消化系恶性肿瘤之一,恶性程度较高,长期以来一直严重威胁着人类的健康,对原发性胆囊癌的早期诊断和治疗至今未取得突破性的进展,是临床急需解决的重要问题.从基因学出发研究原发性胆囊癌的发病机制、早期诊断及治疗,已取得了一定的成绩,也是目前肿瘤研究的热点.本文就目前原发性胆囊癌发病过程中的癌基因、抑癌基因与胆囊癌转移、预后及治疗相关基因,肿瘤标志物的研究状况作以综述.

Primary gallbladder carcinoma （PGC） is a common malignant tumor of the digestive system. As PGC has a high degree of malignancy,it has long posed a serious threat to human health. Early diagnosis and treatment of PGC is important in improving the prognosis of the disease. At present,some achievements have been made in elucidating the pathogenesis of PGC and exploring its early diagnosis and treatment at the genetic level. In this article,we will summarize the recent advances in research on oncogenes and tumor suppressor genes,metastasis-,prognosis-and treatment-related genes,and tumor markers that are associated with PGC.