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Galectin-1蛋白及孕激素受体与胃癌腹膜转移的关系 被引量:1

Association in expression of Galectin-1,PR and the peritoneal metastasis in gastric cancer
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摘要 目的:探讨胃癌组织中半乳糖结合蛋白(Galectin-1)及孕激素受体(PR)表达与胃癌腹膜转移的关系。方法:应用即用型孕激素测定试剂盒及鼠抗人Galectin-1单克隆抗体和免疫组织化学SP染色法检测40例同期伴腹膜转移胃癌患者的癌旁正常胃黏膜、胃癌原发灶、胃癌腹膜转移灶及淋巴结转移灶中Galectin-1蛋白及PR的表达。结果:正常胃黏膜中Galectin-1及PR的表达与胃癌原发灶、腹膜转移灶及淋巴结转移灶之间差异均具统计学意义(P<0.05)。胃癌原发灶、腹膜转移灶及淋巴结转移灶三者间的Galectin-1及PR表达差异无统计学意义(P>0.05)。结论:胃癌病灶中的Galectin-1及PR表达可能成为判断胃癌患者术前是否有腹膜转移及预后的生物学指标,并可为胃癌的内分泌治疗提供依据。 Objective:To investigate the expression of galectin - 1 and progesterone receptor in gastric cancer with peritoneal metastasis. Methods: The expression of galectin - 1 and progesterone receptor were detected in matching -samples including gastric cancer lesions, lymph node metastases, peritoneal metastasis and paratumor normal tissues by immunohistochemistry. All specimens were gained from 40 gastric cancer patients who had synchronous peritoneal metastasis. Results : The expressions of galectin - 1 and progesterone receptor were higher in gastric cancer lesions, the peritoneal metastasis and the lymph node metastases than those in paratumor normal tissues. There were significant differences in expression of galectin - 1 and progesterone receptor between paratumor normal tissues and gastric carci- noma lesions, peritoneal metastasis, lymph node metastases respectively ( P 〈 0.05 ), but there were no significant differences among the gastric carcinoma lesions,peritoneal metastasis and lymph node metastases (P 〉 0.05 ). Con- dusion: The expression of galeetin - 1 and progesterone receptor in gastric cancer lesions can be used as a biological marker of peritoneal metastasis from gastric cancer before operation and as a prognostic factor of gastric cancer.
作者 卿笃桔
出处 《现代肿瘤医学》 CAS 2009年第11期2162-2164,共3页 Journal of Modern Oncology
关键词 GALECTIN-1 孕激素受体 胃肿瘤 腹膜转移 galectin - 1 progesterone receptor (PR) gastric carcinoma peritoneal metastasis
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  • 1Fukumori T,Takenaka Y, Yoshii T, et al. CD29 and CD7 mediate galectin - 1 - induced type IIT - cell apoptosis [ J ]. Cancer Res, 2003,63 (23) :8302.
  • 2Liotta. LAH - ras P21 and the metastatic phenotype [ J ]. J Nail Cancer Inst,2002,80(4) :68.
  • 3Liu AX,Jin F,Zhang WW,et al. Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss [ J]. Biol Reprod, 2006,75 (3) :414 - 420.
  • 4Bozic M, Petronijevic M, Milenkovic S, et al. Galectin - 1 and Galectin - 3 in the trophoblast of the Gestational Trophoblastic disease [ J ]. Placenta,2004,25:797 - 802.
  • 5Moiseeva EP, Willams B, Goodall AH, et al. Galectin - 1 interacts with beta - 1 subunit of integrin [ J ]. Biochem Biophys Res Commu,2003,310(3) :1010.
  • 6Chakraborty A, White SM, Lemer SP. Granulocyte colony - stimulating factor receptor singnals for betal - integrin expression and adhesion in blader cancer[ J]. Urology,2004,63 ( 1 ) : 177.
  • 7Sonjuan X, Femandez PL, Castells A, et al. Difference expression of galectin - 1 and galectin - 3 in gastric cancer progression[ J]. Gastroenterol, 1997,113 (6) : 1906.
  • 8Iurisci I, Tinari N, Natoli C, et al. Concentrations of galectin - 1 in the sera of normal controls and cancer patients [ J ]. Clin Cancer Res,2000,6:1389 -1393.
  • 9Kudo SE, Kashida H, Tamura T, et al. Colonoscopic diagnosis and management of nonpolypoid early gastric cancer[J].Worl J Surg, 2000,24 : 1081.
  • 10Takano N, Lizuka N,Hazama S, et al. Expression of estrogenreceptor alpha and beta mRNA in human gastric cancer [ J ]. Cancer Lett,2002,176 : 129 - 136.

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