摘要
目的:探讨胃癌组织中半乳糖结合蛋白(Galectin-1)及孕激素受体(PR)表达与胃癌腹膜转移的关系。方法:应用即用型孕激素测定试剂盒及鼠抗人Galectin-1单克隆抗体和免疫组织化学SP染色法检测40例同期伴腹膜转移胃癌患者的癌旁正常胃黏膜、胃癌原发灶、胃癌腹膜转移灶及淋巴结转移灶中Galectin-1蛋白及PR的表达。结果:正常胃黏膜中Galectin-1及PR的表达与胃癌原发灶、腹膜转移灶及淋巴结转移灶之间差异均具统计学意义(P<0.05)。胃癌原发灶、腹膜转移灶及淋巴结转移灶三者间的Galectin-1及PR表达差异无统计学意义(P>0.05)。结论:胃癌病灶中的Galectin-1及PR表达可能成为判断胃癌患者术前是否有腹膜转移及预后的生物学指标,并可为胃癌的内分泌治疗提供依据。
Objective:To investigate the expression of galectin - 1 and progesterone receptor in gastric cancer with peritoneal metastasis. Methods: The expression of galectin - 1 and progesterone receptor were detected in matching -samples including gastric cancer lesions, lymph node metastases, peritoneal metastasis and paratumor normal tissues by immunohistochemistry. All specimens were gained from 40 gastric cancer patients who had synchronous peritoneal metastasis. Results : The expressions of galectin - 1 and progesterone receptor were higher in gastric cancer lesions, the peritoneal metastasis and the lymph node metastases than those in paratumor normal tissues. There were significant differences in expression of galectin - 1 and progesterone receptor between paratumor normal tissues and gastric carci- noma lesions, peritoneal metastasis, lymph node metastases respectively ( P 〈 0.05 ), but there were no significant differences among the gastric carcinoma lesions,peritoneal metastasis and lymph node metastases (P 〉 0.05 ). Con- dusion: The expression of galeetin - 1 and progesterone receptor in gastric cancer lesions can be used as a biological marker of peritoneal metastasis from gastric cancer before operation and as a prognostic factor of gastric cancer.
出处
《现代肿瘤医学》
CAS
2009年第11期2162-2164,共3页
Journal of Modern Oncology