循环热灌注化疗治疗恶性腹腔积液疗效观察

Clinical observation on cycle thermochemotherapy of intraperitoneal perfusion for malignant peritoneal effusion

目的:观察循环热灌注化疗治疗恶性腹腔积液的临床疗效。方法:将病理检查确诊的恶性腹腔积液患者56例,随机分为试验组(29例)、对照组(27例)。所有患者经腹腔穿刺及灌洗术后,试验组行腹腔内循环热灌注化疗,对照组仅行热灌注化疗,观察疗效及不良反应。结果:试验组腹水治疗的总有效率为93.1%;对照组为66.7%,有显著性差异(P<0.025)。试验组治疗过程中多汗发生率(89.7%)高于对照组(29.6%),有显著性差异(P<0.05)。结论:腹腔内循环热灌注化疗治疗恶性腹腔积液疗效好、操作简单、不良反应少、患者耐受性好、优势明显。

Objective： To evaluate the efficacy of cycle thermochemotherapy of intraperitoneal perfusion for malignant peritoneal effusion. Methods：Fifty six cases with malignant peritoneal effusion were randomly divided into two groups. After abdominal paracentesis and lavation ,29 cases were treated with cycle thermochemotherapy of intraperitoneally perfusion and 27 cases were treated with thermochemotherapy of intraperitoneally perfusion as control. Then the treatment effect and toxicities were assessed. Results： The response rate was 93.1% in treated group and 66.7% in the control group （P 〈 0. 025 ） . The hyperhidrosis more frequently happened in therapy group （89.7%） than in control group （29.6 % ） （ P 〈 0.05 ） . Conclusion： Cycle thermochemotherapy of intraperitoneal perfusion for malignant peritoneal effusion is an effective and well tolerated method for the malignant peritoneal effusion with slight side - effect .