我国血吸虫疫苗研究进展及应用前景

Research Progress on Schistosome Vaccine and Prospect of its Application in China

血吸虫病疫苗研究一直是WHO/TDR热带病防治和我国血防研究的热点内容,近年来我国有关血吸虫病疫苗的研究取得了重要进展。随着蛋白质组学和分子生物学技术的发展,我国血吸虫病疫苗研究已发展到基因工程疫苗研制阶段。其中DNA疫苗已成为当前我国血吸虫病疫苗研究的主流方向。同时,新的有效疫苗抗原分子的筛选鉴定及其配伍与优化,混合疫苗、多价疫苗的构建及其与佐剂的联用,为提高疫苗免疫保护效果提供了新的途径。

Development of vaccine against schistosomiasis japonica has been incorporated into WHOrl＇DR and China＇s main disease control research programs. In recent years,the research on the anti-schistosomiasis vaccine has made significant progress. With the development of proteomics and molecular biology technology, Anti-Schistosoma japonicum vaccine research has been developed to a stage of genetic engineering in our country and DNA vaccines have become the main direction. It reveals new ways to enhance the immunoprotection of Schistosoma japonicum vaccine through screening new candidate antgens, optimizing combination of the mixed/mnltivalent vaccines, or adjuvant addition.