重组人生长激素对肠道屏障功能的保护作用

Protective Effects of Recombinant Human Growth Hormone on Intestinal Barrier Function

目的探讨重组人生长激素对肠道屏障功能的保护作用及其机理。方法复习近年来国内、外相关文献并进行综述。结果重组人生长激素能使肠黏膜细胞和免疫细胞增殖、防止细胞凋亡,对抗NO、细胞因子及内毒素对屏障功能的损伤,增加肠道对谷氨酰胺的摄取和利用来维持肠黏膜的完整性和功能,以此维持肠道的屏障功能。结论重组人生长激素通过不同的途径保护肠道屏障功能。

Objective To investigate the protective effects and the mechanism of recombinant human growth hormone on the intestinal barrier function. Methods The literatures of recent years were reviewed and summarized. Results The recombinant human growth hormone not only prevent mueosal cells and immunological cells from ap optosis, but also antagonize the damage of NO, cytokines, as well as endotoxin on intestinal barrier. What＇s more, it increases the intestinal uptake and utilization of glutamine. All of the above could maintain the integrity and functions of the intestinal barrier. Conclusion The recombinant human growth hormone protects the intestinal barrier function through different ways.