FAP-1在肺癌中的表达及其临床意义

Expression of FAP-1 Protein in Lung Cancer and Its Clinical Implication

目的:观察肺癌患者癌组织中Fas相关磷酸酯酶(FAP-1)的表达,初步探讨FAP-1表达在肿瘤发生发展中的作用,并分析其意义。方法:采用免疫组织化学SP法检测60例肺癌及15例肺良性病变标本中FAP-1蛋白的表达水平,设置10例正常肺组织为对照组。结果:FAP-1蛋白的阳性表达主要定位在细胞质内,少数也可见胞膜着色。FAP-1蛋白在正常肺组织中未见表达,良性病变中的表达率为6.7%,而在恶性肿瘤中的阳性表达率为78.3%,与前两者相比差异有显著性(P<0.01)。FAP-1的表达与肿瘤的分化程度和转移呈显著相关(P<0.05),与年龄和肿瘤大小无明显相关性(P>0.05)。结论:FAP-1在肺癌组织中有广泛表达,在临床有转移、分期晚和病理分级低的组织中表达增高,可能对于肺癌的发病机制及恶变程度具有重要意义。

Objective：To investigate the roles of Fas-associated phosphatase-1 （FAP-1） in the pathogenesis of lung cancer. Methods：Immunohistochemical SP method was employed to detect the expression of FAP-1 in benign （15 cases）,lung cancer （60 cases） and the normal controls （10 cases）. In addition,clinical pathological data of them were analyzed. Results：No FAP-1 expression in normal controls and low positive expression rate in benign cancer （6.7%）,but high positive expression rate（78.3%） was found in lung carcinoma （P〈0.01）. Moreover,the expression of FAP-1 was markedly associated with patients＇ cancer metastasis and tumor pathological grade （P〈0.05）,but not associated with age and tumor size. Conclusion：FAP-1 is widely overexpressed in lung cancer and its expression is associated with cancer metastasis and pathological grade. It indicates that FAP-1 may play an important role in the etiology and development of lung cancer.