血管内皮生长因子在肺癌患者诊治中的临床价值

Clinical value of serum level of vascular endothelial growth factor to the diagnosis and treatment of lung cancer

目的:探讨血清血管内皮生长因子水平在肺癌诊断和预后中的临床意义。方法:采用ELISA法对49例肺癌患者及20例健康体检者的血清血管内皮生长因子分别进行测定,同时用化学发光法测定肺癌患者血清癌胚抗原的含量。结果:肺癌患者血清血管内皮生长因子水平明显高于健康对照组(P<0.01),肺癌患者血清血管内皮生长因子水平与其生存期之间呈负相关(P<0.01)。血清血管内皮生长因子对肺癌诊断的灵敏度为85.71%,特异度为70%。血清癌胚抗原、血管内皮生长因子及联合检测的阳性率分别为51.02%,85.71%,91.84%,血管内皮生长因子阳性率明显高于血清癌胚抗原。结论:血清血管内皮生长因子是一种良好的肿瘤标记物,对肺癌的诊断和评估预后具有重要的临床价值,其诊断价值优于血清癌胚抗原。

Objective To explore the clinical significance of serum level of vascular endothelial growth factor in the diagnosis and prognosis of lung cancer. Methods The serum level of vascular endothelial growth factor was detected in 49 patients with lung cancer and 20 normal controls with ELISA method, the serum level of carcinoembryanic antigen was detected in 49 patients with lung cancer by chemiluminescence immunoassay. Results The serum level of vascular endothelial growth factor in patients with lung cancer was significantly higher than that of normal controls. The serum level of vascular endothelial growth factor in patients with lung cancer was negatively correlated to survival（P〈0.01）. The sensitivity and specificity of serum vascular endothelial growth factor were 85.71% and 70%. The sensitivity of carcinoembryanic antigen was 51. 02%. The sensitivity of combined determination of two markers was 91.84%. The sensitivity of serum vascular endothelial growth factor was significantly higher than that of serum carcinoembryanic antigen. Conclusion The serum level of vascular endothelial growth factor is a significant tumor marker. It has an important clinical value to the diagnosis and prognosis of lung cancer. Its role in diagnosis of lung cancer is superior to carcinoembryanic antigen.