食管间质瘤的临床特点及病理改变

Clinicopathologic study of gastrointestinal stromal tumors in esophagus

目的:了解食管间质瘤的特殊临床病理改变。方法:收集21例食管间质瘤的临床病理资料,每例常规光镜切片观察,作免疫组织化学SMA,S100,CD34,CD117,CKp抗体等标记。结果:食管间质瘤临床症状以吞咽困难为主,肿瘤直径<3.0cm者17例,>6.0cm的4例。肿瘤无出血坏死,瘤细胞以梭形细胞为主,核分裂0-4个/50HPF。免疫组化染色:CD34阳性20例(20/21),CD117阳性(20/21),SMA阳性20例(20/21),S100蛋白阳性1例(1/21)。结论:食管间质瘤临床症状与食道癌相似,病理改变以良性肿瘤为主。

Objectlve：To investigate the clinicopatholgic feature of gastrintestinal stromal tumors （GISTs） in esophagus. Methods： For 21 FIST cases to observe the feature by light and immunohistochemical assays of CD34, CD117,SMA,S100 and CKp were tested. Results： All 21 cases were benign. The GISTS of esophagus showed spindie cell type in most specimens. CD117 ,CD34 and SMA were positive in most cases. Conclusion： The symptoms of GISTS in esophagus were similar as esophageal carcinoma. Pathologic features were benign.