放化疗综合治疗局部晚期肺癌的疗效分析

Clinical outcome of treating patients with locally advanced non-small cell lung cancer by hyperfractionated radiotherapy and chemotherapy

目的:探讨超分割放疗并化疗治疗局部晚期非小细胞肺癌的疗效和不良反应。方法:1999年1月至2002年12月来院首诊的109例局部晚期非小细胞肺癌患者,采用超分割放疗治疗联合化疗,放疗采用60Co-γ线外照射,1.2Gy/次,2次/d,5d/周,间隔≥6h,全疗程肺部病灶剂量64-84Gy。结果:放疗结束时有效(CR+PR)率为97.2%,1年生存率为46.8%,2年生存率22.0%,5年生存率为8.3%。结论:超分割放疗并化疗患者能耐受,疗效好,为局部晚期非小细胞肺癌患者提供了一种可能有效的治疗选择,其确切疗效有待大规模临床试验验证。

Objective：To approach the therapeutic effects and complication of hyperfractionated radiotherapy and chemotherapy for locally advanced non - small cell lung cancer. Methods： From January 1999 to December 2002, 109 patients with locally advanced non - small cell lung cancer were treated by hyperfractionated radiotherapy and chemotherapy. For hyperfractionated radiotherapy,γ - ray from 60 Co were performed and two daily fractions of 1.2Gy were given,with an interval of ≥6 hours,5 days per week to a dose range of 64Gy -84Gy for lung. Results：The short -term effective rate after treatment was 97.2%. The 1,2 and 5 year survival rates were 46.8% ,22.0% and 8.3%. Conclusion： With this treatment schedule,patient＇s tolerance and therapeutic effect is good. It provids a treatment means for locally advanced non - small cell lung cancer. But it must be validated by the large - scale clinical trials.