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Bcl-2、Caspase-3在大肠癌中的表达及意义 被引量：9

Expression and significance of Bcl-2 and Caspase-3 in colorectal carcinoma
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摘要 目的:探讨结直肠肿瘤中Bcl-2和Caspase-3蛋白的表达及其临床意义。方法:取42例结直肠腺癌、10例正常结直肠黏膜组织,以免疫组化方法(S-P法)检测Bcl-2和Caspase-3蛋白的表达,分析其表达与结直肠腺癌临床病理特征的关系。结果:Bcl-2、Caspase-3在正常组织和大肠癌组织中的表达差异具有统计学意义(P<0.05);Bcl-2和Caspase-3与大肠癌分级有关(P<0.05),但与Dukes分期、淋巴结转移无关(P>0.05)。结论:腺癌组织中Bcl-2和Caspase-3可能参与了结直肠癌的发生、发展过程,对大肠癌及腺癌进行Bcl-2和Caspase-3基因检测有助于大肠癌的早期诊断及预后评估。 Objective：To study the expression and significance of Bcl -2 and Caspase -3 in colorectal carcinoma. Methods ： SP immunohistochemical technique was used to examine the expression of Bcl - 2 and Caspase - 3 in 42 cases of colorectal carcinoma and 25 cases of normal colorectal mucosa. Results： The expressions of Bcl - 2 and Caspase -3 were significantly different in different pathological grading（P 〈 O. 05） and were no significantly different in stages of Dukes and lymphnode metastasis （ P 〉 0.05 ）. Conclusion： The expressions of Bcl - 2 and Caspase - 3 may be closely correlated to the occurrence and development of colorectal carcinoma. Detecting the expression of Bcl - 2 and Caspase - 3 in colorectal carcinoma is useful for the early diagnosis of colorectal carcinoma and evaluation of the prognosis.
作者 邓文英 罗素霞 陈小兵 周孟强 李宁 韩黎丽 马杰 韩广森
机构地区 河南省肿瘤医院内科
出处 《现代肿瘤医学》 CAS 2009年第12期2363-2365,共3页 Journal of Modern Oncology
关键词 结直肠肿瘤 BCL-2 CASPASE-3 免疫组织化学 Bcl - 2 Caspase - 3 colorectal neoplas immunohistochemistry
分类号 R735.34 [医药卫生—肿瘤]
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参考文献6

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二级参考文献11

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现代肿瘤医学
2009年 第12期

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