摘要
目的:探讨胃癌手术对腹腔脱落癌细胞的影响。方法:收集50例行胃癌手术患者胃癌切除前后腹腔冲洗液,以流式细胞学(FCM)方法检测腹腔冲洗液癌胚抗原(CEA)及角蛋白-19(CK-19),同时采用HE染色进行腹腔冲洗液细胞学(PLC)检查。结果:胃癌手术患者CEA检查手术前后阳性率分别为46%(23/50)和64%(32/50),CK-19检查手术前后阳性率为48%(24/50)和68%(34/50),两组之间差异有统计学意义(P<0.05)。PLC检查结果手术前后分别为20%(10/50)和36%(18/50)(P<0.05)。术前、术后PLC阳性者FCM均为阳性。结论:胃癌手术增加腹腔胃癌细胞的脱落。
Objective:To investigate the effect of gastrectomy on gastric cancer cells in peritoneal lavage fluid from patienm with gastric cancer. Methods : Peritoneal lavage fluid from 50 patients with gastric cancer was collected before and after gatrectomy to detect carcinoembryonic antigen (CEA) and cytokeratin - 19 ( CK - 19 ) using FCM. The peritoneal lavage cytology examination(PLC) was carried out by HE staining. Results:The pre - ,and postoperative CEA positive rates were 46% ( 23/50 ) and 64% ( 32/50 ), respectively, and there was significant difference ( P 〈 0.05 ) ; while, the pre -, and postoperative CK - 19 positive rates were 48% (24/50)and 68% (34/50)with significant difference ( P 〈 0.05 ). The pre - , and postoperative PLC positive rates were 20% (10/50) and 36 % (18/50) ( P 〈 0.05 ). Conclusion:Gastrectomy increases the intraperitoneal free cancer cells.
出处
《现代肿瘤医学》
CAS
2009年第12期2368-2371,共4页
Journal of Modern Oncology
基金
全军"十一五"计划面上项目资助(06MA082)