原发性胰腺淋巴瘤临床病理分析及文献回顾

Primary pancreatic lymphoma:clinicopathologic analysis and review of literature

目的:报道1例原发于胰腺体部的淋巴瘤,并结合文献探讨其临床及组织病理学特点。方法:对1例原发性胰腺淋巴瘤进行常规病理及免疫组化观察。结果:显微镜下,肿瘤细胞大小较一致,排列密集,弥漫分布,核深染,圆形或卵圆形,大小不规则。免疫组织化学染色结果示肿瘤细胞表达LCA、CD20、CD79α、Vim-entin,不表达CD45RO、CK、EMA、NSE、Syn、CgA、CD99、CD3。结论:原发性胰腺淋巴瘤极为罕见,临床诊断应排除其他部位淋巴瘤的转移或白血病。

Objective：To report one case of lymphoma occurring primarily in body of pancreas and study its clinical and pathological features. Methods： One case of primary pancreatic lymphoma was investigated by histopathologic and immunohistochemical observation. Results：Microscopically, the tumor cells were uniform in size, and they were arranged with high density and dispersed with suffusion. The nucelus were anaehromasised and irregular in size, and they were round or orbicularovate . In immunohistoehemistry, the tumor ceils were positive for LCA, CD20, CD79ot and Vimentin, but negative for CD45 RO, CK, EMA, NSE, Syn, CgA, CD99 and CD3. Conclusion： Primary pancreatic lymphoma was very rare. It should be differentiated from the lymphomatous metastasis from other place or leukaemia.