Tei指数对阿魏酸钠改善肺心病右心功能的评价

Study of right ventricular function with tei index and sodium ferulate in patients with chronic pulmonary heart disease

目的:探讨右室Tei指数评价内皮素受体拮抗剂(阿魏酸钠)改善肺心病肺动脉高压和右心功能的临床价值。方法:肺心病患者85例随机分为治疗组(40例)和对照组(45例)。治疗组除常规治疗外静脉滴注阿魏酸钠300mg/d,连用20d。治疗前后2组均进行血气分析,并行心脏二维超声检查,测量右心房横径、右室横径、右室前壁厚度、肺主动脉干内径,计算右室射血分数。根据三尖瓣反流估测肺动脉收缩压,根据右室等容收缩时间、等容舒张时间和右室射血时间计算出右室Tei指数。结果:①治疗组、对照组总有效率分别为92.5%、75.7%,差异有统计学意义(P<0.05);②治疗后2组氧分压比较,差异有统计学意义(P<0.05);③2组治疗前后及治疗后组间Tei指数、肺动脉压力变化比较,差异有统计学意义(P<0.05)。结论:阿魏酸钠改善肺心病右心功能及降低肺动脉压力的作用显著,Tei指数是一项方便、准确评价右心功能的超声指标。

Objective：To explore the effect of Tei index and sodium ferulate on right ventricular global function in patients with chronic pulmonary heart disease. Method： The total 85 patients with chronic pulmonary heart disease were randomly divided into two groups. In therapy group （n=40） sodium feulate was added besides the traditional treatment therapy. Control group （n= 45） used traditional treatment therapy. The conventional echo-Dopple： parameters assessed included RA,RVD, RVAM, MPA, RVEF, PASP and Tei index and blood gas analysis were done before and after treatment in two groups. Result： The clinical estimination were evaluated, effective fate was 92. 5% in therapy group and 75.5% in control group（P〈0.05）. Compared with in control group,PaO2, PASP, Tel index were better in therapy group. There were significant differences in PASP and Tei index after treatment in two groups（P〈0. 05）. Conclusion： Sodium ferulate is an effective drug and Tei index is valuable and easy to estimate right ventricular functions with chronic pulmonary heart disease.