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RNAi技术在阿尔采末病防治研究中的应用 被引量：2

Applications of RNAi technology in Alzheimer’s diseases
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摘要 阿尔采末病(Alzheimer′s disease,AD)是一种神经退行性疾病,目前已成为严重威胁老年人生活质量乃至生命的主要疾病之一。由于AD的发病机制并不清楚,因此给其治疗带来了很大困难,目前的治疗方法都只能部分改善症状,而不能逆转病理变化或阻止病情的发展。近年来RNAi技术在体内外抑制AD相关基因表达的成功,为AD的治疗提供了新的方法。该综述主要介绍了RNAi技术在AD中的应用。 Alzheimer′s disease（AD）is one of the neurodegenerative diseases.Now it seriously threatens the life of the elderly.The pathogenesis of AD is not clear,thus there is no cure for this disease.The current treatment can′t reverse the pathological change of the disease or prevent the development of the disease,and the symptoms of the AD patients can only be partly improved.In recent years,the application of RNAi technology to the inhibition of the expression of the AD-related genes provides a new method for the treatment of AD.This article mainly introduces the application of the RNAi technology to AD.
作者 孙琰 周文霞 张永祥
机构地区 军事医学科学院毒物药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第11期1408-1411,共4页 Chinese Pharmacological Bulletin
基金 国家重点基础研究发展规划(973计划)资助项目(No2004CB518907) 国家自然科学基金资助项目(No30772562)
关键词 阿尔采末病 RNAI 基因沉默 Β淀粉样蛋白 BACE1 TAU Alzheimer′s disease RNA interference gene silencing amyloid β-protein BACE1 Tau
分类号 R-05 [医药卫生] R341 [医药卫生—基础医学]
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共引文献4

同被引文献25

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中国药理学通报
2009年 第11期

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